Decreased mebrofenin uptake in patients with non-colorectal liver tumors requiring liver volume augmentation-a single-center analysis.
Extended liver resection
Hepatobiliary scintigraphy
Liver augmentation
PHLF
Journal
Langenbeck's archives of surgery
ISSN: 1435-2451
Titre abrégé: Langenbecks Arch Surg
Pays: Germany
ID NLM: 9808285
Informations de publication
Date de publication:
11 Mar 2024
11 Mar 2024
Historique:
received:
10
09
2023
accepted:
03
03
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
epublish
Résumé
Posthepatectomy liver failure (PHLF) remains a life-threatening complication after hepatectomy. To reduce PHLF, a preoperative assessment of liver function is indispensable. For this purpose, We included all patients undergoing extended liver resections via two-stage procedures between January 2019 and December 2021 at the University Medical Center Hamburg-Eppendorf, Germany. All patients received a preoperative MSPECT. Twenty patients were included. In every fourth patient, PHLF was observed. Four patients had PHLF grade C. There were no differences between patients with CRLM and NCRLT regarding PHLF rate and future liver remnant (FLR) volume. Patients with CRLM had higher mebrofenin uptake in the FLR compared to those with NCRLT (2.49%/min/m Mebrofenin uptake in patients with NCRLT was lower compared to those patients with CRLM. However, there was no difference in the PHLF rate and FLR volume. Cut-off values for the mebrofenin uptake might need adjustments for different surgical indications, surgical procedures, and underlying diseases.
Sections du résumé
BACKGROUND
BACKGROUND
Posthepatectomy liver failure (PHLF) remains a life-threatening complication after hepatectomy. To reduce PHLF, a preoperative assessment of liver function is indispensable. For this purpose,
METHODS
METHODS
We included all patients undergoing extended liver resections via two-stage procedures between January 2019 and December 2021 at the University Medical Center Hamburg-Eppendorf, Germany. All patients received a preoperative MSPECT.
RESULTS
RESULTS
Twenty patients were included. In every fourth patient, PHLF was observed. Four patients had PHLF grade C. There were no differences between patients with CRLM and NCRLT regarding PHLF rate and future liver remnant (FLR) volume. Patients with CRLM had higher mebrofenin uptake in the FLR compared to those with NCRLT (2.49%/min/m
CONCLUSION
CONCLUSIONS
Mebrofenin uptake in patients with NCRLT was lower compared to those patients with CRLM. However, there was no difference in the PHLF rate and FLR volume. Cut-off values for the mebrofenin uptake might need adjustments for different surgical indications, surgical procedures, and underlying diseases.
Identifiants
pubmed: 38467934
doi: 10.1007/s00423-024-03280-5
pii: 10.1007/s00423-024-03280-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
92Informations de copyright
© 2024. The Author(s).
Références
Dokmak S, Fteriche FS, Borscheid R, Cauchy F, Farges O, Belghiti J (2013) 2012 Liver resections in the 21st century: we are far from zero mortality. HPB (Oxford) 15(11):908–915. https://doi.org/10.1111/hpb.12069
doi: 10.1111/hpb.12069
pubmed: 23461811
Narula N, Aloia TA (2017) Portal vein embolization in extended liver resection. Langenbeck's Arch Surg 402(5):727–735. https://doi.org/10.1007/s00423-017-1591-8
doi: 10.1007/s00423-017-1591-8
Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baumgart J, Farkas SA et al (2012) Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg 255(3):405–414. https://doi.org/10.1097/SLA.0b013e31824856f5
doi: 10.1097/SLA.0b013e31824856f5
pubmed: 22330038
Raptis DA, Linecker M, Kambakamba P, Tschuor C, Muller PC, Hadjittofi C et al (2019) Defining benchmark outcomes for ALPPS. Ann Surg 270(5):835–841. https://doi.org/10.1097/SLA.0000000000003539
doi: 10.1097/SLA.0000000000003539
pubmed: 31592812
Truant S, Baillet C, Deshorgue AC, El Amrani M, Huglo D, Pruvot FR (2017) Contribution of hepatobiliary scintigraphy in assessing ALPPS most suited timing. Updat Surg 69(3):411–419. https://doi.org/10.1007/s13304-017-0481-5
doi: 10.1007/s13304-017-0481-5
de Graaf W, van Lienden KP, van Gulik TM, Bennink RJ (2010) (99m)Tc-mebrofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy. J Nucl Med 51(2):229–236. https://doi.org/10.2967/jnumed.109.069724
doi: 10.2967/jnumed.109.069724
pubmed: 20080899
Rassam F, Olthof PB, van Lienden KP, Bennink RJ, Erdmann JI, Swijnenburg RJ et al (2020) Comparison of functional and volumetric increase of the future remnant liver and postoperative outcomes after portal vein embolization and complete or partial associating liver partition and portal vein ligation for staged hepatectomy (ALPPS). Ann Transl Med 8(7):436. https://doi.org/10.21037/atm.2020.03.191
doi: 10.21037/atm.2020.03.191
pubmed: 32395480
pmcid: 7210209
Gupta M, Choudhury PS, Singh S, Hazarika D (2018) Liver functional volumetry by Tc-99m mebrofenin hepatobiliary scintigraphy before major liver resection: a game changer. Indian J Nucl Med 33(4):277–283. https://doi.org/10.4103/ijnm.IJNM_72_18
doi: 10.4103/ijnm.IJNM_72_18
pubmed: 30386047
pmcid: 6194760
Tomassini F, D'Asseler Y, Linecker M, Giglio MC, Castro-Benitez C, Truant S et al (2020) Hepatobiliary scintigraphy and kinetic growth rate predict liver failure after ALPPS: a multi-institutional study. HPB (Oxford) 22(10):1420–1428. https://doi.org/10.1016/j.hpb.2020.01.010
doi: 10.1016/j.hpb.2020.01.010
pubmed: 32057681
Linecker M, Bjornsson B, Stavrou GA, Oldhafer KJ, Lurje G, Neumann U et al (2017) Risk adjustment in ALPPS is associated with a dramatic decrease in early mortality and morbidity. Ann Surg 266(5):779–786. https://doi.org/10.1097/SLA.0000000000002446
doi: 10.1097/SLA.0000000000002446
pubmed: 28806301
Johnson PJ, Berhane S, Kagebayashi C, Satomura S, Teng M, Reeves HL et al (2015) Assessment of liver function in patients with hepatocellular carcinoma: a new evidence-based approach-the ALBI grade. J Clin Oncol 33(6):550–558. https://doi.org/10.1200/JCO.2014.57.9151
doi: 10.1200/JCO.2014.57.9151
pubmed: 25512453
Strasberg SM, Belghiti J, Clavien PA, Gadzijev E, Garden JO, Lau WY et al (2000) The Brisbane 2000 terminology of liver anatomy and resections. HPB. 2(3):333–339. https://doi.org/10.1016/S1365-182X(17)30755-4
doi: 10.1016/S1365-182X(17)30755-4
Rassam F, Olthof PB, Richardson H, van Gulik TM, Bennink RJ (2019) Practical guidelines for the use of technetium-99m mebrofenin hepatobiliary scintigraphy in the quantitative assessment of liver function. Nucl Med Commun 40(4):297–307. https://doi.org/10.1097/MNM.0000000000000973
doi: 10.1097/MNM.0000000000000973
pubmed: 30601245
Ekman M, Fjalling M, Holmberg S, Person H (1992) IODIDA clearance rate: a method for measuring hepatocyte uptake function. Transplant Proc 24(1):387–388
pubmed: 1539327
Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R et al (2011) Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 149(5):713–724. https://doi.org/10.1016/j.surg.2010.10.001
doi: 10.1016/j.surg.2010.10.001
pubmed: 21236455
Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg 240(2):205–213. https://doi.org/10.1097/01.sla.0000133083.54934.ae
doi: 10.1097/01.sla.0000133083.54934.ae
pubmed: 15273542
pmcid: 1360123
Ribero D, Abdalla EK, Madoff DC, Donadon M, Loyer EM, Vauthey JN (2007) Portal vein embolization before major hepatectomy and its effects on regeneration, resectability and outcome. Br J Surg 94(11):1386–1394. https://doi.org/10.1002/bjs.5836
doi: 10.1002/bjs.5836
pubmed: 17583900
Olthof PB, Coelen RJS, Bennink RJ, Heger M, Lam MF, Besselink MG et al (2017) (99m)Tc-mebrofenin hepatobiliary scintigraphy predicts liver failure following major liver resection for perihilar cholangiocarcinoma. HPB (Oxford) 19(10):850–858. https://doi.org/10.1016/j.hpb.2017.05.007
doi: 10.1016/j.hpb.2017.05.007
pubmed: 28687148
Yokoyama Y, Nagino M, Nimura Y (2007) Mechanism of impaired hepatic regeneration in cholestatic liver. J Hepato-Biliary-Pancreat Surg 14(2):159–166. https://doi.org/10.1007/s00534-006-1125-1
doi: 10.1007/s00534-006-1125-1
Balci D, Sakamoto Y, Li J, Di Benedetto F, Kirimker EO, Petrowsky H (2020) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure for cholangiocarcinoma. Int J Surg 82S:97–102. https://doi.org/10.1016/j.ijsu.2020.06.045
doi: 10.1016/j.ijsu.2020.06.045
pubmed: 32645441