Extrathymic AIRE-Expressing Cells: A Historical Perspective.
AIRE
Fertility
Immune periphery
Non-immune function
RORγt+ eTACs
Sertoli cells
Th17 responses
Transcription function
eTACs
mTECs
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2024
2024
Historique:
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
ppublish
Résumé
Since its discovery, Aire has been the topic of numerous studies in its role as a transcriptional regulator in the thymus where it promotes the "promiscuous" expression of a large repertoire of tissue-restricted antigens (TRAs) that are normally expressed only in the immune periphery. This process occurs in specialized medullary thymic epithelial cells (mTECs) and mediates the elimination of self-reactive T cells or promotes their conversion to the Foxp3
Identifiants
pubmed: 38467971
doi: 10.1007/978-981-99-9781-7_3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
33-49Informations de copyright
© 2024. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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