Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension.
Disease
Fibrosis
Integrative aspects of cell biology
Model organism
Transcriptomics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
15 Mar 2024
15 Mar 2024
Historique:
received:
11
09
2023
revised:
10
12
2023
accepted:
16
02
2024
medline:
12
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
epublish
Résumé
Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous regression after the removal of the inducing agents. We linked the dynamics of key disease readouts, such as portal pressure, collagen area, and transaminase levels, to differentially expressed genes, enabling the identification of transcriptomic signatures of progressive vs. regressive liver fibrosis and portal hypertension. These candidate biomarkers (e.g.,
Identifiants
pubmed: 38469563
doi: 10.1016/j.isci.2024.109301
pii: S2589-0042(24)00522-4
pmc: PMC10926212
doi:
Types de publication
Journal Article
Langues
eng
Pagination
109301Informations de copyright
© 2024 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.