The catalytic mechanism of the RNA methyltransferase METTL3.
METTL3
biochemistry
bisubstrate analogue
chemical biology
human
m6A
methyl transfer
molecular biophysics
structural biology
transition state
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 Mar 2024
12 Mar 2024
Historique:
medline:
14
3
2024
pubmed:
12
3
2024
entrez:
12
3
2024
Statut:
epublish
Résumé
The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N
Identifiants
pubmed: 38470714
doi: 10.7554/eLife.92537
pii: 92537
pmc: PMC10932547
doi:
pii:
Substances chimiques
RNA
63231-63-0
Methyltransferases
EC 2.1.1.-
Adenosine
K72T3FS567
S-Adenosylmethionine
7LP2MPO46S
METTL3 protein, human
EC 2.1.1.62
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM141930
Pays : United States
Organisme : Swiss National Science Foundation
ID : 310030-212195
Pays : Switzerland
Organisme : NIH HHS
ID : R35-GM141930
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2023, Corbeski et al.
Déclaration de conflit d'intérêts
IC, PV, RB, JD, DC, EB, LI, YL, DH, ME, AC No competing interests declared, QC Senior editor, eLife
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