A self-assembled 3D model demonstrates how stiffness educates tumor cell phenotypes and therapy resistance in pancreatic cancer.

3D disease model drug resistance pancreatic cancer peptide amphiphile self-assembling hydrogels tumor microenvironment tunable stiffness

Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
12 Mar 2024
Historique:
revised: 16 01 2024
received: 17 08 2023
medline: 12 3 2024
pubmed: 12 3 2024
entrez: 12 3 2024
Statut: aheadofprint

Résumé

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense and stiff extracellular matrix (ECM) associated with tumor progression and therapy resistance. To further our understanding of how stiffening of the tumor microenvironment (TME) contributes to aggressiveness, we develop a three-dimensional (3D) self-assembling hydrogel disease model based on peptide amphiphiles (PAs, PA-E3Y) designed to tailor stiffness. The model displays nanofibrous architectures reminiscent of native TME and enables the study of the invasive behavior of PDAC cells. We demonstrate enhanced tuneability of stiffness by interacting thermally annealed aqueous solutions of PA-E3Y (PA-E3Y

Identifiants

DOI: 10.1002/adhm.202301941 PMID: 38471128
pubmed: 38471128
doi: 10.1002/adhm.202301941
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2301941

Informations de copyright

This article is protected by copyright. All rights reserved.

Auteurs

Ying Liu (Y)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

Babatunde O Okesola (BO)

School of Life Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, NG7 2RD, UK.

David Osuna de la Peña (D)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

Weiqi Li (W)

School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

Meng-Lay Lin (ML)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

Sara Maria David Trabulo (SMD)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

Marianthi Tatari (M)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.

Rita T Lawlor (RT)

Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, 37134, Italy.
ARC-Net, Applied Research on Cancer Centre, University of Verona, Verona, 37134, Italy.

Aldo Scarpa (A)

Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, 37134, Italy.
ARC-Net, Applied Research on Cancer Centre, University of Verona, Verona, 37134, Italy.

Wen Wang (W)

School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.

Martin Knight (M)

Centre for Bioengineering, School of Engineering and Materials Science, Queen Mary University of London, London, E1 4NS, UK.
Centre for Predictive in vitro Models, Queen Mary University of London, London, E1 4NS, UK.

Daniela Loessner (D)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
Department of Chemical and Biological Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3800, Australia.
Department of Materials Science and Engineering, Faculty of Engineering, Monash University, Melbourne, VIC, 3800, Australia.
Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, 3800, Australia.

Christopher Heeschen (C)

Center for Single-Cell Omics, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Pancreatic Cancer Heterogeneity, Candiolo Cancer Institute - FPO - IRCCS, Candiolo (TO), 10060, Italy.

Alvaro Mata (A)

School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Biodiscovery Institute, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Department of Chemical and Environmental Engineering, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
ORCID: 0000-0002-6739-9111

Oliver M T Pearce (OMT)

Barts Cancer Institute, Queen Mary University of London, London, EC1M 6BQ, UK.
ORCID: 0000-0003-3953-1629

Classifications MeSH