Esculin inhibits hepatic stellate cell activation and CCl

BACKGROUND

Liver fibrosis (LF) is a pathological process of the liver that threatens human health. Currently, effective treatments are still lacking. Esculin, a prominent constituent found in the Fraxinus rhynchophylla. (bark), Aesculus hippocastanum. (bark), and Cichorium intybus. (herb), has been shown to possess significant anti-inflammatory, antioxidant, and antibacterial properties. However, to date, there have been no studies investigating its potential efficacy in the treatment of LF.

OBJECTIVE

The study aims to investigate the therapeutic effect of esculin on LF and elucidate its potential molecular mechanism.

METHODS

Carbon tetrachloride (CCl

RESULTS

Esculin significantly inhibited CCl

CONCLUSION

This study is the first to demonstrate that esculin is a potential natural active ingredient in the treatment of LF, which can inhibit the activation of hepatic stellate cells (HSC) and improve LF. Its therapeutic effect is related to the activation of the Nrf2/GPX4 signaling pathway.

Informations de copyright

Copyright © 2024. Published by Elsevier GmbH.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.