Stereoselective Analysis of the Antiseizure Activity of Fenfluramine and Norfenfluramine in Mice: Is

anticonvulsant activity chiral switch enantioselectivity fenfluramine norfenfluramine pharmacokinetic-pharmacodynamic correlation

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
21 Feb 2024
Historique:
received: 20 12 2023
revised: 13 02 2024
accepted: 13 02 2024
medline: 13 3 2024
pubmed: 13 3 2024
entrez: 13 3 2024
Statut: epublish

Résumé

The aim of this study was to investigate the comparative antiseizure activity of the

Identifiants

DOI: 10.3390/ijms25052522 PMID: 38473769
pubmed: 38473769
pii: ijms25052522
doi: 10.3390/ijms25052522
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Natalia Erenburg (N)

Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.

Emilio Perucca (E)

Department of Medicine (Austin Health), University of Melbourne, Heidelberg, VIC 3084, Australia.
Department of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC 3168, Australia.

Jeff Bechard (J)

Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Celine Dube (C)

Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Nina Weishaupt (N)

Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Robin Sherrington (R)

Xenon Pharmaceuticals Inc., 3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

Meir Bialer (M)

Institute of Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.
David R. Bloom Center for Pharmacy, The Hebrew University of Jerusalem, Jerusalem 9112002, Israel.

Classifications MeSH