Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food.

PCNs Polychlorinated naphthalenes feed food risk assessment

Journal

EFSA journal. European Food Safety Authority
ISSN: 1831-4732
Titre abrégé: EFSA J
Pays: United States
ID NLM: 101642076

Informations de publication

Date de publication:
Mar 2024
Historique:
medline: 13 3 2024
pubmed: 13 3 2024
entrez: 13 3 2024
Statut: epublish

Résumé

EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results were used to estimate dietary exposures for food-producing and non-food-producing animals; however, a risk characterisation could not be performed because none of the toxicological studies allowed identification of reference points. The oral repeated dose toxicity studies performed in rats with a hexaCN mixture containing all 10 hexaCNs indicated that the critical target was the haematological system. A BMDL

Identifiants

pubmed: 38476320
doi: 10.2903/j.efsa.2024.8640
pii: EFS28640
pmc: PMC10928787
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e8640

Informations de copyright

© 2024 European Food Safety Authority. EFSA Journal published by Wiley‐VCH GmbH on behalf of European Food Safety Authority.

Déclaration de conflit d'intérêts

If you wish to access the declaration of interests of any expert contributing to an EFSA scientific assessment, please contact interestmanagement@efsa.europa.eu.

Auteurs

Classifications MeSH