An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations.

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
13 Mar 2024
Historique:
medline: 13 3 2024
pubmed: 13 3 2024
entrez: 13 3 2024
Statut: ppublish

Résumé

Inhibitors of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (M

Identifiants

DOI: 10.1126/scitranslmed.adi0979 PMID: 38478629
pubmed: 38478629
doi: 10.1126/scitranslmed.adi0979
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadi0979

Auteurs

Michael Westberg (M)

Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
Interdisciplinary Nanoscience Center (iNANO), Aarhus University, 8000 Aarhus C, Denmark.
ORCID: 0000-0002-2312-5282

Yichi Su (Y)

Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China.
ORCID: 0000-0001-5715-835X

Xinzhi Zou (X)

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0002-3382-2401

Pinghan Huang (P)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
ORCID: 0000-0003-2460-0695

Arjun Rustagi (A)

Department of Medicine, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0002-6921-1012

Jaishree Garhyan (J)

Stanford In Vitro Biosafety Level 3 Service Center, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0002-1657-8320

Puja Bhavesh Patel (PB)

Stanford In Vitro Biosafety Level 3 Service Center, Stanford University, Stanford, CA 94305, USA.

Daniel Fernandez (D)

Program in Chemistry, Engineering, and Medicine for Human Health (ChEM-H), Stanford University, Stanford, CA 94305, USA.
Sarafan ChEM-H, Macromolecular Structure Knowledge Center, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0002-6221-152X

Yan Wu (Y)

Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0003-2596-1943

Chenzhou Hao (C)

Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0001-6803-7270

Chieh-Wen Lo (CW)

Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Marwah Karim (M)

Department of Medicine, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0003-0990-3962

Lin Ning (L)

Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.

Aimee Beck (A)

Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Panatda Saenkham-Huntsinger (P)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
ORCID: 0000-0001-9598-7255

Vivian Tat (V)

Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
ORCID: 0009-0002-0274-3900

Aleksandra Drelich (A)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
ORCID: 0000-0002-0201-5017

Bi-Hung Peng (BH)

Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA.
ORCID: 0000-0003-1323-2241

Shirit Einav (S)

Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA.
Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
ORCID: 0000-0001-6441-4171

Chien-Te K Tseng (CK)

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
Department of Neuroscience, Cell Biology, and Anatomy, University of Texas Medical Branch, Galveston, TX 77555, USA.
ORCID: 0000-0001-5726-9834

Catherine Blish (C)

Department of Medicine, Stanford University, Stanford, CA 94305, USA.
Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
ORCID: 0000-0001-6946-7627

Michael Z Lin (MZ)

Department of Neurobiology, Stanford University, Stanford, CA 94305, USA.
Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
Department of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
ORCID: 0000-0002-0492-1961

Classifications MeSH