Rho-kinase inhibitor alleviates CD4

Corneal transplantation STAT Th17 Treg Y27632

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
11 Mar 2024
Historique:
received: 30 07 2023
revised: 14 12 2023
accepted: 03 01 2024
medline: 14 3 2024
pubmed: 14 3 2024
entrez: 13 3 2024
Statut: aheadofprint

Résumé

Penetrating keratoplasty remains the most common treatment to restore vision for corneal diseases. Immune rejection after corneal transplantation is one of the major causes of graft failure. In recent years, Rho-associated protein kinase (ROCK) inhibitors have been found to be associated with the activation of the STATs pathway and are widely studied in autoimmune diseases. Therefore, it may be possible that the ROCK inhibitors also participate in the local and systemic immune regulation in corneal transplantation through activation of the STATs pathway and affect the CD4

Identifiants

DOI: 10.1016/j.exer.2024.109857 PMID: 38479724
pubmed: 38479724
pii: S0014-4835(24)00078-2
doi: 10.1016/j.exer.2024.109857
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109857

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Auteurs

Shang Li (S)

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China.

Peng Zhang (P)

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China.

Ao Li (A)

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China.

Jiayu Bao (J)

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China.

Zhiqiang Pan (Z)

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China.

Ying Jie (Y)

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, Beijing, China. Electronic address: jie_yingcn@aliyun.com.

Classifications MeSH