Mitochondrial complex I activity in microglia sustains neuroinflammation.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
13 Mar 2024
Historique:
received: 03 10 2022
accepted: 06 02 2024
medline: 14 3 2024
pubmed: 14 3 2024
entrez: 14 3 2024
Statut: aheadofprint

Résumé

Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark of several chronic neurological diseases, including multiple sclerosis

Identifiants

pubmed: 38480879
doi: 10.1038/s41586-024-07167-9
pii: 10.1038/s41586-024-07167-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

L Peruzzotti-Jametti (L)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK. lp429@cam.ac.uk.
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. lp429@cam.ac.uk.

C M Willis (CM)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

G Krzak (G)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

R Hamel (R)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

L Pirvan (L)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

R-B Ionescu (RB)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

J A Reisz (JA)

Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.

H A Prag (HA)

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

M E Garcia-Segura (ME)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

V Wu (V)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Y Xiang (Y)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

B Barlas (B)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
UK Dementia Research Institute, University of Cambridge, Cambridge, UK.

A M Casey (AM)

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

A M R van den Bosch (AMR)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

A M Nicaise (AM)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

L Roth (L)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

G R Bates (GR)

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

H Huang (H)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

P Prasad (P)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

A E Vincent (AE)

Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

C Frezza (C)

University Hospital Cologne, Cologne, Germany.

C Viscomi (C)

University of Padua, Padova, Italy.

G Balmus (G)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.
UK Dementia Research Institute, University of Cambridge, Cambridge, UK.
Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania.

Z Takats (Z)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

J C Marioni (JC)

European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Genome Campus, Hinxton, UK.

A D'Alessandro (A)

Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, USA.

M P Murphy (MP)

MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.

I Mohorianu (I)

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

S Pluchino (S)

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK. spp24@cam.ac.uk.

Classifications MeSH