Associations between arterial health and sexual function in women aged 60-64 years.
ankle-brachial index
arterial health
blood pressure
late middle-aged women
sexual dysfunction
sexual health
woman
Journal
Acta obstetricia et gynecologica Scandinavica
ISSN: 1600-0412
Titre abrégé: Acta Obstet Gynecol Scand
Pays: United States
ID NLM: 0370343
Informations de publication
Date de publication:
14 Mar 2024
14 Mar 2024
Historique:
revised:
22
02
2024
received:
15
10
2023
accepted:
24
02
2024
medline:
14
3
2024
pubmed:
14
3
2024
entrez:
14
3
2024
Statut:
aheadofprint
Résumé
Female sexual dysfunction is very common, but its determinants remain under-investigated. Vasculogenic impairments are suggested to be related to female sexual dysfunction, but previous literature regarding the association is scarce. This study aims to study the association between arterial health and female sexual function in women in their 60s. The sample for this cross-sectional study comprised 117 women (aged 60-64 years) who participated in the Finnish Retirement and Aging study. Arterial health was measured according to the participants' pulse wave velocity, ankle-brachial index, blood pressure, and pulse pressure. Sexual function was measured using the Female Sexual Function Index, which resulted in a total score and six sub-scores. Associations were examined using multivariable regression analyses, which were adjusted for age, relationship happiness, systemic menopausal hormone therapy and/or local estrogen, smoking, alcohol risk use, body mass index, and depressive symptoms. Higher diastolic blood pressure was associated with a higher total Female Sexual Function Index score (β = 0.24, 95% confidence interval [CI] 0.07-0.41) and with higher desire (β = 0.02, 95% CI 0.01-0.04), arousal (β = 0.04, 95% CI 0.01-0.08), lubrication (β = 0.04, 95% CI 0.002-0.08), satisfaction (β = 0.03, 95% CI 0.003-0.05), and pain (β = 0.06, 95% CI 0.02-0.10) sub-scores. Also, higher ankle-brachial index was associated with higher satisfaction sub-score (β = 2.10, 95% CI 0.44-3.73) and lower pulse pressure was associated with higher orgasm sub-score (β = 0.03, 95% CI 0.0002-0.06). Other associations between ankle-brachial index and Female Sexual Function Index scores were statistically insignificant, but considering the magnitude the findings may imply clinical significance. Systolic blood pressure and pulse wave velocity were not associated with sexual function. This study suggested a plausible association between higher diastolic blood pressure and female sexual function, but considering clinical significance our findings suggest an association between higher ankle-brachial index and good sexual function in women in their 60s.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Valtion tutkimusrahoitus (Turun yliopistollinen keskussairaala)
ID : 286294
Organisme : Valtion tutkimusrahoitus (Turun yliopistollinen keskussairaala)
ID : 294154
Organisme : Valtion tutkimusrahoitus (Turun yliopistollinen keskussairaala)
ID : 319246
Organisme : Juho Vainion Säätiö
Organisme : Opetus- ja Kulttuuriministeriö
Informations de copyright
© 2024 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).
Références
Basson R, Leiblum S, Brotto L, et al. Revised definitions of women's sexual dysfunction. J Sex Med. 2004;1:40-48.
McCool ME, Zuelke A, Theurich MA, Knuettel H, Ricci C, Apfelbacher C. Prevalence of female sexual dysfunction among premenopausal women: a systematic review and meta-analysis of observational studies. Sex Med Rev. 2016;4:197-212.
Romano Marquez Reis SC, Martins Pinto J, Porcatti A, et al. Predictive factors for the risk of sexual dysfunction in climacteric women: population-based study. J Sex Med. 2022;19:1546-1552.
Miner M, Esposito K, Guay A, Montorsi P, Goldstein I. Cardiometabolic risk and female sexual health: the Princeton III summary (CME). J Sex Med. 2012;9:641-651.
Maseroli E, Scavello I, Vignozzi L. Cardiometabolic risk and female sexuality-part I. Risk factors and potential pathophysiological underpinnings for female Vasculogenic sexual dysfunction syndromes. Sex Med Rev. 2018;6:508-524.
Traish AM, Botchevar E, Kim NN. Biochemical factors modulating female genital sexual arousal physiology. J Sex Med. 2010;7:2925-2946.
Lara LA, Cartagena-Ramos D, Figueiredo JBP, et al. Hormone therapy for sexual function in perimenopausal and postmenopausal women. Cochrane Database Syst Rev. 2023;8:CD009672.
Ingram CF, Payne KS, Messore M, Scovell JM. Testosterone therapy and other treatment modalities for female sexual dysfunction. Curr Opin Urol. 2020;30:309-316.
Matz RL, Schott C, Stoclet JC, Andriantsitohaina R. Age-related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products. Physiol Res. 2000;49:11-18.
Triggle CR, Hollenberg M, Anderson TJ, et al. The endothelium in health and disease-a target for therapeutic intervention. J Smooth Muscle Res. 2003;39:249-267.
Lunelli RP, Irigoyen MC, Goldmeier S. Hypertension as a risk factor for female sexual dysfunction: cross-sectional study. Rev Bras Enferm. 2018;71:2477-2482.
Doumas M, Tsiodras S, Tsakiris A, et al. Female sexual dysfunction in essential hypertension: a common problem being uncovered. J Hypertens. 2006;24:2387-2392.
Choy CL, Sidi H, Koon CS, et al. Systematic review and meta-analysis for sexual dysfunction in women with hypertension. J Sex Med. 2019;16:1029-1048.
Zhong Q, Anderson Y. Management of Hypertension with female sexual dysfunction. Medicina (B Aires). 2022;58:637.
Lee YY, Rhee MH. Atherosclerosis. Pgs. 265-75. In Recent Advancements in Microbial Diversity: Macrophages and their Role in Inflammation. Jae Youl Cho. Academic Press; 2023.
Lahoz C, Mostaza JM. Atherosclerosis As a systemic disease. Rev Esp Cardiol. 2007;60:184-195.
Kaya C, Yilmaz G, Nurkalem Z, Ilktac A, Karaman MI. Sexual function in women with coronary artery disease: a preliminary study. Int J Impot Res. 2007;19:326-329.
Premužić V, Jelaković B. Sexual dysfunction as a determinant of cardiovascular outcome in patients undergoing chronic hemodialysis. Int J Impot Re. 2018;30:14-20.
Stenholm S, Pulakka A, Leskinen T, et al. Daily physical activity patterns and their association with health-related physical fitness among aging workers-the Finnish retirement and aging study. J Gerontol A Biol Sci Med Sci. 2021;76:1242-1250.
Leskinen T, Pulakka A, Heinonen OJ, et al. Changes in non-occupational sedentary behaviours across the retirement transition: the Finnish retirement and aging (FIREA) study. J Epidemiol Community Health. 2018;72:695-701.
Lindroos AS, Johansson JK, Puukka PJ, et al. The association between home vs. ambulatory night-time blood pressure and end-organ damage in the general population. J Hypertens. 2016;34:1730-1737.
Van Bortel LM, Laurent S, Boutouyrie P, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30:445-448.
Norgren L, Hiatt WR, Bell K, et al. Inter-society consensus for the Management of Peripheral Arterial Disease (TASC II). Eur J Vasc Endovasc Surg. 2007;33(Suppl):1-S75.
Jula A, Kantola I, Korhonen P, et al. Hypertension. Current Care Guidelines. Working Group Set up by the Finnish Medical Society Duodecim and the Finnish Hypertension Society. The Finnish Medical Society Duodecim, 2020. Accessed January 3, 2023. https://www.kaypahoito.fi/en/ccs00014
Homan TD, Bordes S, Cichowski E. Physiology, pulse pressure. StatPearls. 2022; Accessed August 19, 2022 https://www.ncbi.nlm.nih.gov/books/NBK482408/
Rosen R, Brown C, Heiman J, et al. The female sexual function index (Fsfi): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther. 2000;26:191-205.
Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther. 2005;31:1-20.
Moolman JA. Unravelling the cardioprotective mechanism of action of estrogens. Cardiovasc Res. 2006;69:777-780.
Da SGMD, Lima SMRR, Dos RBF, Macruz CF, Postigo S. Evaluation of obesity influence in the sexual function of postmenopausal women: a cross-sectional study. Rev Bras Ginecol Obstet. 2019;41:660-667.
Salari N, Hasheminezhad R, Abdolmaleki A, et al. The effects of smoking on female sexual dysfunction: a systematic review and meta-analysis. Arch Womens Ment Health. 2022;25:1021-1027.
Salari N, Hasheminezhad R, Almasi A, et al. The risk of sexual dysfunction associated with alcohol consumption in women: a systematic review and meta-analysis. BMC Womens Health. 2023;23:213.
McCool-Myers M, Theurich M, Zuelke A, Knuettel H, Apfelbacher C. Predictors of female sexual dysfunction: a systematic review and qualitative analysis through gender inequality paradigms. BMC Womens Health. 2018;18:108.
Hoek AG, van Oort S, Mukamal KJ, Beulens JWJ. Alcohol consumption and cardiovascular disease risk: placing new data in context. Curr Atheroscler Rep. 2022;24:51-59.
Van der Kooy K, van Hout H, Marwijk H, Marten H, Stehouwer C, Beekman A. Depression and the risk for cardiovascular diseases: systematic review and meta analysis. Int J Geriatr Psychiatry. 2007;22:613-626.
Hajar R. Risk factors for coronary artery disease: historical perspectives. Heart Views. 2017;18:109-114.
Työterveyslaitos Ja Sosiaali-Ja Terveysministeriö [Finnish Institute of Occupatinal Health and Finnish Ministry of Social Affairs and Health]. Riskikulutuksen varhainen tunnistaminen ja mini-interventio-hoitosuosituksen yhteenveto [adapted translation into Finnish based on: Anderson P., Gual A., Colom. (2005) Alcohol and Primary Health Care: Clinical Guidelines on identification and Brief Interventions. Department of Health of the Government of Catalonia: Barcelona]. 2006. Accessed March 25, 2023 www.phepa.net
Wang YP, Gorenstein C. Psychometric properties of the Beck depression inventory-II: a comprehensive review. Braz J Psychiatry. 2013;35:416-431.
Franklin SS, Gustin W IV, Wong ND, et al. Hemodynamic patterns of age-related changes in blood pressure: the Framingham heart study. Circulation. 1997;96:308-315.
Hulin I, Kinova S, Paulis L, Slavkovsky P, Duris I. Diastolic blood pressure as a major determinant of tissue perfusion: potential clinical consequences. Bratisl Lek Listy. 2010;111:54-56.
Berman JR, Adhikari SP, Goldstein I. Anatomy and physiology of female sexual function and dysfunction: classification, evaluation and treatment options. Eur Urol. 2000;38:20-29.
Park K, Goldstein I, Andry C, Siroky MB, Krane RJ, Azadzoi KM. Vasculogenic female sexual dysfunction: the hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res. 1997;9:27-37.
Foy C, Newman J, Berlowitz D, et al. Blood pressure, sexual activity, and dysfunction in women with hypertension: baseline findings from the systolic blood pressure intervention trial (SPRINT). J Sex Med. 2016;13:1333-1346.
Nilsson PM. Hemodynamic aging as the consequence of structural changes associated with early vascular aging (EVA). Aging Dis. 2014;5:109-113.
Ignarro LJ, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol. 1999;34:879-886.
Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res. 2012;35:1039-1047.
Musicki B, Liu T, Lagoda GA, Bivalacqua TJ, Strong TD, Burnett AL. Endothelial nitric oxide synthase regulation in female genital tract structures. J Sex Med. 2009;6(Suppl 3):247-253.
Armeni A, Armeni E, Augoulea A, et al. Sexual dysfunction is associated with arterial stiffness in postmenopausal women. J Sex Med. 2024;21:145-152.
Düsing P, Zietzer A, Goody PR, et al. Vascular pathologies in chronic kidney disease: pathophysiological mechanisms and novel therapeutic approaches. J Mol Med (Berl). 2021;99:335-348.
Basson R, Gilks T. Women's sexual dysfunction associated with psychiatric disorders and their treatment. Womens Health (Lond). 2018;14:1745506518762664.
Dunne MP, Martin NG, Michael Bailey J, et al. Participation bias in a sexuality survey: psychological and behavioural characteristics of responders and non-responders. Int J Epidemiol. 1997;26:844-854.
Meston CM, Freihart BK, Handy AB, Kilimnik CD, Rosen RC. Scoring and interpretation of the FSFI: what can be learned from 20 years of use? J Sex Med. 2020;17:17-25.
Latif EZ, Diamond MP. Arriving at the diagnosis of female sexual dysfunction. Fertil Steril. 2013;100:898-904.
Anderson D, Laforge J, Ross MM, et al. Male sexual dysfunction. Health. Psychol Res. 2022;10:37533.
Çayan S, Bozlu M, Canpolat B, Akbay E. The assessment of sexual functions in women with male partners complaining of erectile dysfunction: does treatment of male sexual dysfunction improve female partner's sexual functions? J Sex Marital Ther. 2004;30:333-341.