Dermatoscopic patterns of cutaneous metastases: A multicentre cross-sectional study of the International Dermoscopy Society.
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
14 Mar 2024
14 Mar 2024
Historique:
received:
08
12
2023
accepted:
14
02
2024
medline:
14
3
2024
pubmed:
14
3
2024
entrez:
14
3
2024
Statut:
aheadofprint
Résumé
The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours. Retrospective, multicentre, descriptive, cross-sectional study of biopsy-proven CMs. We included 583 patients (247 females, median age: 64 years, 25%-75% percentiles: 54-74 years) with 632 CMs, of which 52.2% (n = 330) were local, and 26.7% (n = 169) were distant. The most common primary tumours were melanomas (n = 474) and breast cancer (n = 59). Most non-melanoma CMs were non-pigmented (n = 151, 95.6%). Of 169 distant metastases, 54 (32.0%) appeared on the head and neck region. On dermatoscopy, pigmented melanoma metastases were frequently structureless blue (63.6%, n = 201), while amelanotic metastases were typified by linear serpentine vessels and a white structureless pattern. No significant difference was found between amelanotic melanoma metastases and CMs of other primary tumours. The head and neck area is a common site for distant CMs. Our study confirms that most pigmented melanoma metastasis are structureless blue on dermatoscopy and may mimic blue nevi. Amelanotic metastases are typified by linear serpentine vessels and a white structureless pattern, regardless of the primary tumour.
Sections du résumé
BACKGROUND
BACKGROUND
The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge.
OBJECTIVES
OBJECTIVE
Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours.
METHODS
METHODS
Retrospective, multicentre, descriptive, cross-sectional study of biopsy-proven CMs.
RESULTS
RESULTS
We included 583 patients (247 females, median age: 64 years, 25%-75% percentiles: 54-74 years) with 632 CMs, of which 52.2% (n = 330) were local, and 26.7% (n = 169) were distant. The most common primary tumours were melanomas (n = 474) and breast cancer (n = 59). Most non-melanoma CMs were non-pigmented (n = 151, 95.6%). Of 169 distant metastases, 54 (32.0%) appeared on the head and neck region. On dermatoscopy, pigmented melanoma metastases were frequently structureless blue (63.6%, n = 201), while amelanotic metastases were typified by linear serpentine vessels and a white structureless pattern. No significant difference was found between amelanotic melanoma metastases and CMs of other primary tumours.
CONCLUSIONS
CONCLUSIONS
The head and neck area is a common site for distant CMs. Our study confirms that most pigmented melanoma metastasis are structureless blue on dermatoscopy and may mimic blue nevi. Amelanotic metastases are typified by linear serpentine vessels and a white structureless pattern, regardless of the primary tumour.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Scott W Menzies
(SW)
Sakitha Maljini
(S)
H Peter Soyer
(HP)
Alessandro Di Stefani
(A)
Teresa Maria Kränke
(TM)
Paweł Pietkiewicz
(P)
Martyna Sławińska
(M)
Michał Sobjanek
(M)
Zsuzsanna Lengyel
(Z)
Verche Todorovska
(V)
Zeljko Mijuskovic
(Z)
Tatjana Radevic
(T)
Sladjana Cekic
(S)
Savoia Francesco
(S)
María Belén Marín
(MB)
Rosario Peralta
(R)
Danijela Popovic
(D)
Konstantinos Liopyris
(K)
Giulia Briatico
(G)
Informations de copyright
© 2024 European Academy of Dermatology and Venereology.
Références
Lookingbill DP, Spangler N, Sexton FM. Skin involvement as the presenting sign of internal carcinoma: a retrospective study of 7316 cancer patients. J Am Acad Dermatol. 1990;22(1):19-26.
Lookingbill DP, Spangler N, Helm KF. Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients. J Am Acad Dermatol. 1993;29(2):228-236.
Spencer PS, Helm TN. Skin metastases in cancer patients. Cutis. 1987;39(2):119-121.
Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol. 1995;33:161-182.
Krathen RA, Orengo IF, Rosen T. Cutaneous metastasis: a meta-analysis of data. South Med J. 2003;96(2):164-167.
Rosen T. Cutaneous metastases. Med Clin North Am. 1980;64:885-900.
Nashan D, Müller ML, Braun-Falco M, Reichenberger S, Szeimies RM, Bruckner-Tuderman L. Cutaneous metastases of visceral tumours: a review. J Cancer Res Clin Oncol. 2009;135:1-14.
Bono R, Giampetruzzi AR, Concolino F, Puddu P, Scoppola A, Sera F, et al. Dermoscopic patterns of cutaneous melanoma metastases. Melanoma Res. 2004;14(5):367-373.
Jaimes N, Halpern JA, Puig S, Malvehy J, Myskowski PL, Braun RP, et al. Dermoscopy: an aid to the detection of amelanotic cutaneous melanoma metastases. Dermatol Surg. 2012;38(9):1437-1444.
Costa J, Ortiz-Ibañez K, Salerni G, Borges V, Carrera C, Puig S, et al. Dermoscopic patterns of melanoma metastases: interobserver consistency and accuracy for metastasis recognition. Br J Dermatol. 2013;169(1):91-99.
Chernoff KA, Marghoob AA, Lacouture ME, Deng L, Busam KJ, Myskowski PL. Dermoscopic findings in cutaneous metastases. JAMA Dermatol. 2014;150(4):429-433.
Kostaki M, Plaka M, Moustaki M, Befon A, Champsas G, Kypreou K, et al. Cutaneous melanoma metastases: clinical and dermoscopic findings. J Eur Acad Dermatol Venereol. 2023;37:941-944.
Plaza JA, Torres-Cabala C, Evans H, Diwan HA, Suster S, Prieto VG. Cutaneous metastases of malignant melanoma: a clinicopathologic study of 192 cases with emphasis on the morphologic spectrum. Am J Dermatopathol. 2010;32(2):129-136.
Savoia P, Fava P, Nardò T, Osella-Abate S, Quaglino P, Bernengo MG. Skin metastases of malignant melanoma: a clinical and prognostic survey. Melanoma Res. 2009;19:321-326.
Keung EZ, Gershenwald JE. The eighth edition American joint committee on cancer (AJCC) melanoma staging system: implications for melanoma treatment and care. Expert Rev Anticancer Ther. 2018;18(8):775-784.
Vernemmen AIP, Li X, Roemen GMJM, Speel EM, Kubat B, Hausen AZ, et al. Cutaneous metastases of internal malignancies: a single-institution experience. Histopathology. 2022;81(3):329-341.