Endogenous retrovirus HERVH-derived lncRNA
Urothelial Cancer Associated 1
endogenous retrovirus
preeclampsia
trophoblast stem cell
trophoblast syncytialization
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
19 Mar 2024
19 Mar 2024
Historique:
medline:
18
3
2024
pubmed:
14
3
2024
entrez:
14
3
2024
Statut:
ppublish
Résumé
Endogenous retroviruses (ERVs) are frequently reactivated in mammalian placenta. It has been proposed that ERVs contribute to shaping the gene regulatory network of mammalian trophoblasts, dominantly acting as species- and placental-specific enhancers. However, whether and how ERVs control human trophoblast development through alternative pathways remains poorly understood. Besides the well-recognized function of human endogenous retrovirus-H (HERVH) in maintaining pluripotency of early human epiblast, here we present a unique role of HERVH on trophoblast lineage development. We found that the LTR7C/HERVH subfamily exhibits an accessible chromatin state in the human trophoblast lineage. Particularly, the LTR7C/HERVH-derived
Identifiants
pubmed: 38483994
doi: 10.1073/pnas.2318176121
doi:
Substances chimiques
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2318176121Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.