Functional neuroimaging in patients with catatonia: A systematic review.

Catatonia Functional neuroimaging PET-CT SPECT fMRI

Journal

Journal of psychosomatic research
ISSN: 1879-1360
Titre abrégé: J Psychosom Res
Pays: England
ID NLM: 0376333

Informations de publication

Date de publication:
11 Mar 2024
Historique:
received: 25 12 2023
revised: 02 03 2024
accepted: 05 03 2024
medline: 15 3 2024
pubmed: 15 3 2024
entrez: 14 3 2024
Statut: aheadofprint

Résumé

Catatonia is a challenging and heterogeneous neuropsychiatric syndrome of motor, affective and behavioral dysregulation which has been associated with multiple disorders such as structural brain lesions, systemic diseases, and psychiatric disorders. This systematic review summarized and compared functional neuroimaging abnormalities in catatonia associated with psychiatric and medical conditions. Using PRISMA methods, we completed a systematic review of 6 databases from inception to February 7th, 2024 of patients with catatonia that had functional neuroimaging performed. A total of 309 studies were identified through the systematic search and 62 met the criteria for full-text review. A total of 15 studies reported patients with catatonia associated with a psychiatric disorder (n = 241) and one study reported catatonia associated with another medical condition, involving patients with N-methyl-d-aspartate receptor antibody encephalitis (n = 23). Findings varied across disorders, with hyperactivity observed in areas like the prefrontal cortex (PFC), the supplementary motor area (SMA) and the ventral pre-motor cortex in acute catatonia associated to a psychiatric disorder, hypoactivity in PFC, the parietal cortex, and the SMA in catatonia associated to a medical condition, and mixed metabolic activity in the study on catatonia linked to a medical condition. Findings support the theory of dysfunction in cortico-striatal-thalamic, cortico-cerebellar, anterior cingulate-medial orbitofrontal, and lateral orbitofrontal networks in catatonia. However, the majority of the literature focuses on schizophrenia spectrum disorders, leaving the pathophysiologic characteristics of catatonia in other disorders less understood. This review highlights the need for further research to elucidate the pathophysiology of catatonia across various disorders.

Sections du résumé

BACKGROUND BACKGROUND
Catatonia is a challenging and heterogeneous neuropsychiatric syndrome of motor, affective and behavioral dysregulation which has been associated with multiple disorders such as structural brain lesions, systemic diseases, and psychiatric disorders. This systematic review summarized and compared functional neuroimaging abnormalities in catatonia associated with psychiatric and medical conditions.
METHODS METHODS
Using PRISMA methods, we completed a systematic review of 6 databases from inception to February 7th, 2024 of patients with catatonia that had functional neuroimaging performed.
RESULTS RESULTS
A total of 309 studies were identified through the systematic search and 62 met the criteria for full-text review. A total of 15 studies reported patients with catatonia associated with a psychiatric disorder (n = 241) and one study reported catatonia associated with another medical condition, involving patients with N-methyl-d-aspartate receptor antibody encephalitis (n = 23). Findings varied across disorders, with hyperactivity observed in areas like the prefrontal cortex (PFC), the supplementary motor area (SMA) and the ventral pre-motor cortex in acute catatonia associated to a psychiatric disorder, hypoactivity in PFC, the parietal cortex, and the SMA in catatonia associated to a medical condition, and mixed metabolic activity in the study on catatonia linked to a medical condition.
CONCLUSION CONCLUSIONS
Findings support the theory of dysfunction in cortico-striatal-thalamic, cortico-cerebellar, anterior cingulate-medial orbitofrontal, and lateral orbitofrontal networks in catatonia. However, the majority of the literature focuses on schizophrenia spectrum disorders, leaving the pathophysiologic characteristics of catatonia in other disorders less understood. This review highlights the need for further research to elucidate the pathophysiology of catatonia across various disorders.

Identifiants

DOI: 10.1016/j.jpsychores.2024.111640 PMID: 38484496
pubmed: 38484496
pii: S0022-3999(24)00052-7
doi: 10.1016/j.jpsychores.2024.111640
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111640

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors have no competing interests to report.

Auteurs

Laura Duque (L)

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: lduqueserrano@mgh.harvard.edu.

Mohammad Ghafouri (M)

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Nicolas A Nunez (NA)

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, University of Utah, Salt Lake City, UT, USA.

Juan Pablo Ospina (JP)

Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.

Kemuel L Philbrick (KL)

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

John D Port (JD)

Department of Radiology, Mayo Clinic, Rochester, MN, USA.

Rodolfo Savica (R)

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Larry J Prokop (LJ)

Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, USA.

Teresa A Rummans (TA)

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry, Mayo Clinic, Jacksonville, Florida.

Balwinder Singh (B)

Department of Psychiatry & Psychology, Mayo Clinic, Rochester, MN, USA.

Classifications MeSH