Epidemiology of Postoperative Junctional Ectopic Tachycardia in Infants Undergoing Cardiac Surgery.


Journal

The Annals of thoracic surgery
ISSN: 1552-6259
Titre abrégé: Ann Thorac Surg
Pays: Netherlands
ID NLM: 15030100R

Informations de publication

Date de publication:
12 Mar 2024
Historique:
received: 11 12 2023
revised: 28 01 2024
accepted: 04 03 2024
medline: 15 3 2024
pubmed: 15 3 2024
entrez: 14 3 2024
Statut: aheadofprint

Résumé

Junctional ectopic tachycardia (JET) complicates congenital heart surgery in 2-8.3% of cases. JET is associated with postoperative morbidity in single-center studies. We utilized the Pediatric Cardiac Critical Care Consortium data registry for the first multicenter epidemiologic description of treated JET. This is a retrospective study (2/2019 - 8/2022) of patients with treated JET. 1) <12 months old at index operation; 2) treated for JET <72 hours after surgery. Diagnosis defined by receiving treatment (pacing, cooling, medications). A multilevel logistic regression analysis with hospital random effect identified JET risk factors. Impact of JET on outcomes was estimated via margins/attributable risk analysis using previous risk-adjustment models. 1436/24,073 (6.0%) patients from 63 centers were treated for JET with significant center variability (0% - 17.9%). Median time to onset was 3.4 hours with 34% present on admission. Median duration was 2 (IQR 1, 4) days. Tetralogy of Fallot (TOF), atrioventricular canal, and ventricular septal defect (VSD) repair represented >50% of JET. Patient characteristics independently associated with JET included neonatal age, Asian race, cardiopulmonary bypass time, open sternum, and early postoperative inotropes. JET was associated with increased risk-adjusted durations of mechanical ventilation (IRR 1.6, 95% CI 1.5-1.7) and ICU length of stay (IRR 1.3, 95% CI 1.2-1.3), but not mortality. JET is treated in 6% of patients with substantial center variability. JET contributes to increased postoperative resource utilization. High center variability warrants further study to identify potential modifiable factors which could serve as targets for improvement efforts to ameliorate deleterious outcomes.

Sections du résumé

BACKGROUND BACKGROUND
Junctional ectopic tachycardia (JET) complicates congenital heart surgery in 2-8.3% of cases. JET is associated with postoperative morbidity in single-center studies. We utilized the Pediatric Cardiac Critical Care Consortium data registry for the first multicenter epidemiologic description of treated JET.
METHODS METHODS
This is a retrospective study (2/2019 - 8/2022) of patients with treated JET.
INCLUSION METHODS
1) <12 months old at index operation; 2) treated for JET <72 hours after surgery. Diagnosis defined by receiving treatment (pacing, cooling, medications). A multilevel logistic regression analysis with hospital random effect identified JET risk factors. Impact of JET on outcomes was estimated via margins/attributable risk analysis using previous risk-adjustment models.
RESULTS RESULTS
1436/24,073 (6.0%) patients from 63 centers were treated for JET with significant center variability (0% - 17.9%). Median time to onset was 3.4 hours with 34% present on admission. Median duration was 2 (IQR 1, 4) days. Tetralogy of Fallot (TOF), atrioventricular canal, and ventricular septal defect (VSD) repair represented >50% of JET. Patient characteristics independently associated with JET included neonatal age, Asian race, cardiopulmonary bypass time, open sternum, and early postoperative inotropes. JET was associated with increased risk-adjusted durations of mechanical ventilation (IRR 1.6, 95% CI 1.5-1.7) and ICU length of stay (IRR 1.3, 95% CI 1.2-1.3), but not mortality.
CONCLUSIONS CONCLUSIONS
JET is treated in 6% of patients with substantial center variability. JET contributes to increased postoperative resource utilization. High center variability warrants further study to identify potential modifiable factors which could serve as targets for improvement efforts to ameliorate deleterious outcomes.

Identifiants

pubmed: 38484909
pii: S0003-4975(24)00185-1
doi: 10.1016/j.athoracsur.2024.03.002
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Michael E Kim (ME)

Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: michaele.kim@sickkids.ca.

Shankar Baskar (S)

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Christopher M Janson (CM)

Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.

Stephanie F Chandler (SF)

Department of Cardiology, Lurie Children's Hospital, Chicago, IL.

Robert D Whitehill (RD)

Division of Cardiology, Children's Healthcare of Atlanta, Atlanta, GA.

Audrey Dionne (A)

Department of Cardiology, Boston Children's Hospital, Boston, MA.

Mark A Law (MA)

Division of Pediatric Cardiology, University of Alabama at Birmingham, Birmingham, AL.

Yuliya Domnina (Y)

Department of Cardiac Critical Care, Children's National Hospital, Washington, DC.

Melissa N Smith-Parrish (MN)

Monroe Carell Jr. Children's Hospital at Vanderbilt, Vanderbilt University School of Medicine, Nashville, TN.

Geoffrey L Bird (GL)

Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA.

Mousumi Banerjee (M)

C.S. Mott Children's Hospital Congenital Heart Center, Ann Arbor, MI.

Wenying Zhang (W)

C.S. Mott Children's Hospital Congenital Heart Center, Ann Arbor, MI.

Garrett Reichle (G)

C.S. Mott Children's Hospital Congenital Heart Center, Ann Arbor, MI.

Kurt R Schumacher (KR)

C.S. Mott Children's Hospital Congenital Heart Center, Ann Arbor, MI.

Richard J Czosek (RJ)

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

David Ls Morales (DL)

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Jeffrey A Alten (JA)

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Classifications MeSH