Bibenzyl-phenylpropane Hybrids with Immunosuppressive Activities from Dendrobium nobile Lindl.

Dendrobium nobile Lindl bibenzyl-phenylpropane immunosuppressive activities

Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
14 Mar 2024
Historique:
revised: 14 03 2024
received: 02 02 2024
accepted: 14 03 2024
medline: 15 3 2024
pubmed: 15 3 2024
entrez: 14 3 2024
Statut: aheadofprint

Résumé

Fifteen bibenyls and four fluorenones, including five new bibenzyl-phenylpropane hybrids, were isolated from the aerial part of Dendrobium nobile Lindl. Their structures were determined by spectroscopic methods. Bioassay on the LPS-induced proliferations of mouse splenic B lymphocytes, and Con A-induced T lymphocytes showed that compounds 1, 2, and 14 showed excellent immunosuppressive activities with IC50 values of 1.23, 1.01, and 3.87 μM, respectively, while compounds 3-4, 7, 10, 13, and 15 exhibited moderate immunosuppressive activities with IC50 values ranging from 6.89 to 14.2 μM.

Identifiants

DOI: 10.1002/cbdv.202400283 PMID: 38485665
pubmed: 38485665
doi: 10.1002/cbdv.202400283
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202400283

Informations de copyright

© 2024 Wiley-VCH GmbH.

Auteurs

Qing-Tao Wang (QT)

Yunnan Normal University, School of Chemistry and Chemical Engineering, No.798, Jvxian Street, Kunming, CHINA.

Chao-Fan Wang (CF)

Yunnan Normal University, School of Chemistry and Chemical Engineering, No.798, Jvxian Street, Kunming, CHINA.

Ying Liu (Y)

Yunnan Normal University, School of Chemistry and Chemical Engineering, No.798, Jvxian Street, Kunming, CHINA.

Rui Zhan (R)

Yunnan Normal University, School of Chemistry and Chemical Engineering, No. 798, Jvxian Street, 650500, Kunming, CHINA.

Classifications MeSH