Clinical Pharmacokinetics and Pharmacodynamics of Naloxone.


Journal

Clinical pharmacokinetics
ISSN: 1179-1926
Titre abrégé: Clin Pharmacokinet
Pays: Switzerland
ID NLM: 7606849

Informations de publication

Date de publication:
14 Mar 2024
Historique:
accepted: 07 02 2024
medline: 15 3 2024
pubmed: 15 3 2024
entrez: 15 3 2024
Statut: aheadofprint

Résumé

Naloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respiratory depression of opioids, also by lay-people witnessing an opioid overdose. Naloxone acts by competitive displacement of opioid agonists at the μ-opioid receptor (MOR). Its effect depends on pharmacological characteristics of the opioid agonist, such as dissociation rate from the MOR receptor and constitution of the victim. Aim of treatment is a balancing act between restoration of respiration (not consciousness) and avoidance of withdrawal, achieved by titration to response after initial doses of 0.4-2 mg. Naloxone is rapidly eliminated [half-life (t

Identifiants

pubmed: 38485851
doi: 10.1007/s40262-024-01355-6
pii: 10.1007/s40262-024-01355-6
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Teijo I Saari (TI)

Department of Anaesthesiology and Intensive Care, University of Turku, Turku, Finland.
Division of Perioperative Services, Intensive Care and Pain Medicine, Turku University Hospital, Turku, Finland.

John Strang (J)

National Addiction Centre, Institute of Psychiatry Psychology and Neuroscience, King's College London, London, SE5 8BB, UK.

Ola Dale (O)

Department of Circulation and Medical Imaging, NTNU-Norwegian University of Science and Technology, Trondheim, Norway. ola.dale@ntnu.no.

Classifications MeSH