Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics.

Humans Platelet Aggregation Inhibitors / pharmacology Calcium / metabolism Thrombin / metabolism Calcium Signaling Platelet Membrane Glycoproteins / metabolism Receptor, PAR-1 / metabolism Blood Platelets / metabolism Platelet Activation Calcium, Dietary / pharmacology Platelet Aggregation Phenothiazines
Collagen Cytosolic calcium Glycoprotein VI Prestwick library Thrombin Thrombosis

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
14 03 2024
Historique:
received: 10 01 2024
accepted: 11 03 2024
medline: 18 3 2024
pubmed: 15 3 2024
entrez: 15 3 2024
Statut: epublish

Résumé

Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin. This is reflected in the different platelet Ca

Identifiants

DOI: 10.1038/s41598-024-56799-4 PMID: 38486006 PMC: PMC10940705
pubmed: 38486006
doi: 10.1038/s41598-024-56799-4
pii: 10.1038/s41598-024-56799-4
pmc: PMC10940705
doi:

Substances chimiques

Platelet Aggregation Inhibitors 0
profenamine 7WI4P02YN1
Calcium SY7Q814VUP
Thrombin EC 3.4.21.5
Platelet Membrane Glycoproteins 0
Receptor, PAR-1 0
Calcium, Dietary 0
Phenothiazines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6229

Subventions

Organisme : European Union's Horizon 2020 research and innovation program under the Marie Slodowska-Curie grant agreement
ID : 76118
Organisme : Agence Nationale de la Recherche
ID : ANR-10-IAHU-04
Organisme : China Scholarship Council
ID : 201909370052

Informations de copyright

© 2024. The Author(s).

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Auteurs

Delia I Fernández (DI)

The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.
Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

Sara Troitiño (S)

Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

Vladimír Sobota (V)

IHU-LIRYC, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, 33604, Bordeaux, France.
Institut de Mathématiques de Bordeaux, UMR5251, University of Bordeaux, 33 405, Talence, France.

Bibian M E Tullemans (BME)

The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.
Synapse Research Institute, Kon. Emmaplein 7, 6217 KD, Maastricht, The Netherlands.

Jinmi Zou (J)

The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands.
Synapse Research Institute, Kon. Emmaplein 7, 6217 KD, Maastricht, The Netherlands.

Helma van den Hurk (H)

Pivot Park Screening Centre, 5349 AB, Oss, The Netherlands.

Ángel García (Á)

Platelet Proteomics Group, CiMUS, Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.

Saman Honarnejad (S)

Pivot Park Screening Centre, 5349 AB, Oss, The Netherlands.

Marijke J E Kuijpers (MJE)

The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands. marijke.kuijpers@maastrichtuniversity.nl.
Thrombosis Expertise Centre, Heart and Vascular Centre, Maastricht University Medical Centre+, 6229 HX, Maastricht, The Netherlands. marijke.kuijpers@maastrichtuniversity.nl.

Johan W M Heemskerk (JWM)

The Department of Biochemistry, CARIM, Maastricht University, 6229 ER, Maastricht, The Netherlands. jwmheem722@outlook.com.
Synapse Research Institute, Kon. Emmaplein 7, 6217 KD, Maastricht, The Netherlands. jwmheem722@outlook.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Antiagrégants plaquettaires › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Thrombine › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Glycoprotéines de membrane plaquettaire › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs activés par la protéinase › Récepteurs à la thrombine › Récepteur de type PAR-1 › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du calcium › Calcium alimentaire › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Agrégation plaquettaire › Ultra-high throughput-based screening for the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénothiazines › Ultra-high throughput-based screening for the...