Papillary renal cell carcinoma with extensive spindle cell foci: mimicker of mucinous tubular and spindle cell carcinoma.
Carcinoma, Papillary
Hippo Signaling Pathway
Immunohistochemistry
Kidney Neoplasms
Nephrectomy
Journal
Autopsy & case reports
ISSN: 2236-1960
Titre abrégé: Autops Case Rep
Pays: Brazil
ID NLM: 101640070
Informations de publication
Date de publication:
2024
2024
Historique:
received:
26
09
2023
accepted:
15
02
2024
medline:
15
3
2024
pubmed:
15
3
2024
entrez:
15
3
2024
Statut:
epublish
Résumé
Papillary renal cell carcinoma (PRCC) is the second most common renal cell carcinoma (RCC), accounting for 10-15% of cases. Mucinous tubular and spindle cell carcinoma (MTSCC), on the other hand, accounts for only 1% of renal tumors and has a more favorable prognosis compared to PRCC. We report a 75-year-old female with a left upper pole solid renal mass displaying features of both papillary renal cell carcinoma (PRCC) and mucinous tubular and spindle cell carcinoma (MTSC). In this case, a shaggy luminal surface, multiple papillations, and psammoma bodies, absence of E-cadherin expression, and strong CD10 expression favored PRCC. Both immunohistochemistry and genomic analysis are critical to diagnose and differentiate tumors that may have overlapping features accurately.
Identifiants
pubmed: 38487036
doi: 10.4322/acr.2024.479
pii: acrep185323_EN
pmc: PMC10939180
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e2024479Informations de copyright
Copyright: © 2024 The Authors.
Déclaration de conflit d'intérêts
Conflict of interest: None.