Identification and characterization of a novel CASR mutation causing familial hypocalciuric hypercalcemia.

calcimimetics calcium-sensing receptor familial hypocalciuric hypercalcemia half-maximal effective concentration parathyroid hormone

Journal

Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782

Informations de publication

Date de publication:
2024
Historique:
received: 08 09 2023
accepted: 22 01 2024
medline: 18 3 2024
pubmed: 15 3 2024
entrez: 15 3 2024
Statut: epublish

Résumé

Although a monoallelic mutation in the calcium-sensing receptor ( A 45-year-old male presenting with moderate hypercalcemia, hypocalciuria, and inappropriately high parathyroid hormone (PTH) had a good response to cinacalcet (total serum calcium (Ca Sanger sequencing of the This proband was found to carry a This novel

Identifiants

pubmed: 38487341
doi: 10.3389/fendo.2024.1291160
pmc: PMC10937390
doi:

Substances chimiques

Receptors, Calcium-Sensing 0
Calcium SY7Q814VUP
CASR protein, human 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1291160

Informations de copyright

Copyright © 2024 Lin, Ding, Huang, Chen, Lee, Sung and Lin.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Chien-Ming Lin (CM)

Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Yi-Xuan Ding (YX)

Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Shih-Ming Huang (SM)

Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.

Ying-Chuan Chen (YC)

Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan.

Hwei-Jen Lee (HJ)

Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan.

Chih-Chien Sung (CC)

Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Shih-Hua Lin (SH)

Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

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Classifications MeSH