Redirecting raltitrexed from cancer cell thymidylate synthase to


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
15 Mar 2024
Historique:
medline: 18 3 2024
pubmed: 15 3 2024
entrez: 15 3 2024
Statut: ppublish

Résumé

There is a compelling need to find drugs active against

Identifiants

pubmed: 38489355
doi: 10.1126/sciadv.adj6406
pmc: PMC10942122
doi:

Substances chimiques

phosphopantetheinyl transferase 0
raltitrexed FCB9EGG971
Thymidylate Synthase EC 2.1.1.45
Bacterial Proteins 0
Quinazolines 0
Thiophenes 0
Transferases (Other Substituted Phosphate Groups) EC 2.7.8.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadj6406

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Auteurs

Amrita Singh (A)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

Samantha Ottavi (S)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Inna Krieger (I)

Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX 77843, USA.

Kyle Planck (K)

Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.

Andrew Perkowski (A)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Takushi Kaneko (T)

Global Alliance for TB Drug Development, New York, NY 10005, USA.

Andrew M Davis (AM)

Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.

Christine Suh (C)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

David Zhang (D)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

Laurent Goullieux (L)

Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.

Alexander Alex (A)

AMG Consultants Limited, Camburgh House, 27 New Dover Road, Canterbury, Kent, CT1 3DN, UK.
Evenor Consulting Limited, The New Barn, Mill Lane, Eastry, Kent CT13 0JW, UK.

Christine Roubert (C)

Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.

Mark Gardner (M)

AMG Consultants Limited, Camburgh House, 27 New Dover Road, Canterbury, Kent, CT1 3DN, UK.

Marian Preston (M)

Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.

Dave M Smith (DM)

Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, UK.

Yan Ling (Y)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

Julia Roberts (J)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

Bastien Cautain (B)

Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.

Anna Upton (A)

Evotec ID (Lyon), SAS 40 Avenue Tony Garnier, Lyon 69001, France.

Christopher B Cooper (CB)

Global Alliance for TB Drug Development, New York, NY 10005, USA.

Natalya Serbina (N)

Global Alliance for TB Drug Development, New York, NY 10005, USA.

Zaid Tanvir (Z)

Global Alliance for TB Drug Development, New York, NY 10005, USA.

John Mosior (J)

Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX 77843, USA.

Ouathek Ouerfelli (O)

Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Guangli Yang (G)

Organic Synthesis Core, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Ben S Gold (BS)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

Kyu Y Rhee (KY)

Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.

James C Sacchettini (JC)

Department of Biochemistry and Biophysics, Texas Agricultural and Mechanical University, College Station, TX 77843, USA.

Nader Fotouhi (N)

Global Alliance for TB Drug Development, New York, NY 10005, USA.

Jeffrey Aubé (J)

Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Carl Nathan (C)

Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York 10021, USA.

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Classifications MeSH