Cellular energy regulates mRNA degradation in a codon-specific manner.
mRNA Stability; Cellular Energy Metabolism; Tissue-specific Regulation; Codon Usage Bias; Codon Optimality-mediated mRNA Degradation
Journal
Molecular systems biology
ISSN: 1744-4292
Titre abrégé: Mol Syst Biol
Pays: England
ID NLM: 101235389
Informations de publication
Date de publication:
15 Mar 2024
15 Mar 2024
Historique:
received:
04
07
2023
accepted:
20
02
2024
revised:
19
02
2024
medline:
16
3
2024
pubmed:
16
3
2024
entrez:
16
3
2024
Statut:
aheadofprint
Résumé
Codon optimality is a major determinant of mRNA translation and degradation rates. However, whether and through which mechanisms its effects are regulated remains poorly understood. Here we show that codon optimality associates with up to 2-fold change in mRNA stability variations between human tissues, and that its effect is attenuated in tissues with high energy metabolism and amplifies with age. Mathematical modeling and perturbation data through oxygen deprivation and ATP synthesis inhibition reveal that cellular energy variations non-uniformly alter the effect of codon usage. This new mode of codon effect regulation, independent of tRNA regulation, provides a fundamental mechanistic link between cellular energy metabolism and eukaryotic gene expression.
Identifiants
pubmed: 38491213
doi: 10.1038/s44320-024-00026-9
pii: 10.1038/s44320-024-00026-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : 403584255
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : 403584255
Organisme : Bundesministerium für Bildung und Forschung (BMBF)
ID : 031L0174A
Organisme : Vetenskapsrådet (VR)
ID : VR 2020-01480 and VR 2021-06112
Organisme : Wallenberg Academy Fellowship
ID : KAW 2021.0167
Organisme : VINNOVA (Swedish Governmental Agency for Innovation Systems)
ID : 2020-03620
Informations de copyright
© 2024. The Author(s).
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