Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor.
Acute kidney injury
Aryl hydrocarbon receptor
Chronic kidney disease
Diabetic nephropathy
Uremic toxins
Journal
Cellular & molecular biology letters
ISSN: 1689-1392
Titre abrégé: Cell Mol Biol Lett
Pays: England
ID NLM: 9607427
Informations de publication
Date de publication:
15 Mar 2024
15 Mar 2024
Historique:
received:
18
10
2023
accepted:
19
02
2024
medline:
18
3
2024
pubmed:
16
3
2024
entrez:
16
3
2024
Statut:
epublish
Résumé
Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due to the decline in renal function. Therefore, AhR is also considered to be a uremic toxin receptor. As a ligand-activated transcriptional factor, the activation of AhR is involved in cell differentiation and senescence, lipid metabolism and fibrogenesis. The accumulation of uremic toxins in the body is hazardous to all tissues and organs. The identification of the endogenous uremic toxin receptor opens the door to investigating the precise role and molecular mechanism of tissue and organ damage induced by uremic toxins. This review focuses on summarizing recent findings on the role of AhR activation induced by uremic toxins in chronic kidney disease, diabetic nephropathy and acute kidney injury. Furthermore, potential clinical approaches to mitigate the effects of uremic toxins are explored herein, such as enhancing uremic toxin clearance through dialysis, reducing uremic toxin production through dietary interventions or microbial manipulation, and manipulating metabolic pathways induced by uremic toxins through controlling AhR signaling. This information may also shed light on the mechanism of uremic toxin-induced injury to other organs, and provide insights into clinical approaches to manipulate the accumulated uremic toxins.
Identifiants
pubmed: 38491448
doi: 10.1186/s11658-024-00550-4
pii: 10.1186/s11658-024-00550-4
pmc: PMC10943832
doi:
Substances chimiques
Uremic Toxins
0
Indican
N187WK1Y1J
Receptors, Aryl Hydrocarbon
0
Toxins, Biological
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
38Subventions
Organisme : National Natural Science Foundation of China
ID : 82170696
Organisme : National Natural Science Foundation of China
ID : 81873609
Organisme : National Natural Science Foundation of China
ID : 82300834
Organisme : National Natural Science Foundation of China
ID : 82370695
Organisme : Science and Technology Commission of Shanghai Municipality
ID : 18411960900
Informations de copyright
© 2024. The Author(s).
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