O-GlcNAcylation: a pro-survival response to acute stress in the cardiovascular and central nervous systems.
Cardioprotection
Hexosamine biosynthetic pathway
Neuroprotection
O-GlcNAcylation
Stress tolerance
Journal
European journal of medical research
ISSN: 2047-783X
Titre abrégé: Eur J Med Res
Pays: England
ID NLM: 9517857
Informations de publication
Date de publication:
16 Mar 2024
16 Mar 2024
Historique:
received:
19
08
2023
accepted:
06
03
2024
medline:
18
3
2024
pubmed:
16
3
2024
entrez:
16
3
2024
Statut:
epublish
Résumé
O-GlcNAcylation is a unique monosaccharide modification that is ubiquitously present in numerous nucleoplasmic and mitochondrial proteins. The hexosamine biosynthesis pathway (HBP), which is a key branch of glycolysis, provides the unique sugar donor UDP-GlcNAc for the O-GlcNAc modification. Thus, HBP/O-GlcNAcylation can act as a nutrient sensor to perceive changes in nutrient levels and trigger O-GlcNAc modifications of functional proteins in cellular (patho-)physiology, thereby regulating diverse metabolic processes. An imbalance in O-GlcNAcylation has been shown to be a pathogenic contributor to dysfunction in metabolic diseases, including type 2 diabetes, cancer, and neurodegeneration. However, under acute stress conditions, protein O-GlcNAc modification exhibits rapid and transient upregulation, which is strongly correlated with stress tolerance and cell survival. In this context, we discuss the metabolic, pharmacological and genetic modulation of HBP/O-GlcNAc modification in the biological system, the beneficial role of O-GlcNAcylation in regulating stress tolerance for cardioprotection, and neuroprotection, which is a novel and rapidly growing field. Current evidence suggests that transient activation of the O-GlcNAc modification represents a potent pro-survival signalling pathway and may provide a promising strategy for stress-related disorder therapy.
Identifiants
pubmed: 38491477
doi: 10.1186/s40001-024-01773-z
pii: 10.1186/s40001-024-01773-z
pmc: PMC10943874
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
174Subventions
Organisme : Priority Academic Program Development of Jiangsu Higher Education Institutions
ID : PAPD
Organisme : Municipal Health Commission of Nantong
ID : MSZ2022048
Organisme : National Natural Science Foundation of China
ID : 81401094
Informations de copyright
© 2024. The Author(s).
Références
J Mol Cell Cardiol. 2008 Aug;45(2):313-25
pubmed: 18539296
J Biol Chem. 2016 Dec 16;291(51):26515-26528
pubmed: 27816939
Cell Metab. 2017 Feb 7;25(2):374-385
pubmed: 28178567
Mol Brain. 2021 Jan 9;14(1):6
pubmed: 33422108
Nat Rev Mol Cell Biol. 2020 Dec;21(12):729-749
pubmed: 33087899
Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H142-53
pubmed: 24186210
Neuroreport. 2021 Feb 3;32(3):214-222
pubmed: 33470760
Proc Natl Acad Sci U S A. 2015 May 12;112(19):6050-5
pubmed: 25918408
J Biol Chem. 2009 Jan 2;284(1):547-555
pubmed: 19004814
Biochem Biophys Res Commun. 2006 Feb 10;340(2):526-34
pubmed: 16376298
Crit Care Med. 2010 Feb;38(2):562-71
pubmed: 20016375
Arch Toxicol. 2015 Mar;89(3):289-317
pubmed: 25618543
J Cereb Blood Flow Metab. 2021 Nov;41(11):3111-3126
pubmed: 34176340
Anesthesiology. 2011 Nov;115(5):955-62
pubmed: 21876430
Circulation. 2008 Mar 4;117(9):1172-82
pubmed: 18285568
Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2227-36
pubmed: 17208994
J Biol Chem. 2005 Mar 25;280(12):11018-24
pubmed: 15647256
Biochim Biophys Acta. 2015 Aug;1853(8):1860-9
pubmed: 25937070
Nat Chem Biol. 2011 Mar;7(3):174-81
pubmed: 21258330
Neuromolecular Med. 2022 Sep;24(3):299-310
pubmed: 34705256
Bioorg Med Chem Lett. 2011 Nov 1;21(21):6264-9
pubmed: 21958546
Biochem J. 2009 May 13;420(2):221-7
pubmed: 19275764
Int J Mol Sci. 2015 Jul 21;16(7):16560-75
pubmed: 26197318
J Biol Chem. 2004 Jul 16;279(29):30133-42
pubmed: 15138254
Br J Anaesth. 2022 Nov;129(5):703-715
pubmed: 36031420
J Biol Chem. 2014 Jun 6;289(23):15927-41
pubmed: 24742675
Exp Neurol. 2021 May;339:113646
pubmed: 33600817
J Biol Chem. 1984 Mar 10;259(5):3308-17
pubmed: 6421821
J Biol Chem. 2020 Dec 11;295(50):17071-17082
pubmed: 33023909
Biochemistry. 1996 Mar 19;35(11):3578-86
pubmed: 8639509
J Am Chem Soc. 2006 Dec 27;128(51):16484-5
pubmed: 17177381
Annu Rev Physiol. 2005;67:225-57
pubmed: 15709958
Membranes (Basel). 2020 Oct 21;10(10):
pubmed: 33096926
Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1715-27
pubmed: 20833964
Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H335-42
pubmed: 18469144
Crit Care. 2013 Mar 06;17(2):305
pubmed: 23470218
Circ Res. 2009 Jan 2;104(1):41-9
pubmed: 19023128
Cell Mol Life Sci. 2003 Feb;60(2):222-8
pubmed: 12678487
Circulation. 2019 Aug 13;140(7):580-594
pubmed: 31195810
Physiol Rev. 2021 Apr 1;101(2):427-493
pubmed: 32730113
J Orthop Surg Res. 2018 Jul 6;13(1):170
pubmed: 29980200
J Biol Chem. 2010 Dec 10;285(50):39096-107
pubmed: 20926391
Molecules. 2021 Sep 28;26(19):
pubmed: 34641427
Shock. 2006 Jun;25(6):600-7
pubmed: 16721268
J Cereb Blood Flow Metab. 2016 Feb;36(2):393-8
pubmed: 26661187
J Neuroinflammation. 2023 Jun 22;20(1):146
pubmed: 37349834
Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H515-23
pubmed: 19098112
Biomedicines. 2023 Apr 24;11(5):
pubmed: 37238930
Neth Heart J. 2005 Jun;13(6):233-238
pubmed: 25696497
J Biol Chem. 2017 Feb 3;292(5):1724-1736
pubmed: 27927986
Minerva Anestesiol. 2011 May;77(5):488-95
pubmed: 21540803
J Cereb Blood Flow Metab. 2017 Aug;37(8):2938-2951
pubmed: 27864466
Circulation. 2022 Aug 16;146(7):503-505
pubmed: 35969651
Heart Surg Forum. 2020 Feb 25;23(1):E063-E069
pubmed: 32118546
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1711-9
pubmed: 19734355
J Am Chem Soc. 2018 Oct 24;140(42):13542-13545
pubmed: 30285435
Stroke. 2017 Jun;48(6):1646-1654
pubmed: 28487326
Ann Rheum Dis. 2020 Oct;79(10):1261-1263
pubmed: 32554393
Glia. 2010 Nov 15;58(15):1881-92
pubmed: 20737476
Best Pract Res Clin Endocrinol Metab. 2001 Dec;15(4):533-51
pubmed: 11800522
Circulation. 2021 Apr 27;143(17):1687-1703
pubmed: 33593071
Cardiovasc Res. 2013 Feb 1;97(2):369-78
pubmed: 23201773
Biochim Biophys Acta. 2012 Jun;1818(6):1444-50
pubmed: 22062421
Circulation. 2011 Jan 18;123(2):170-7
pubmed: 21200004
Curr Eye Res. 2020 May;45(5):556-562
pubmed: 31920129
Carbohydr Polym. 2014 Jan;99:568-78
pubmed: 24274545
Int J Mol Sci. 2018 Jan 30;19(2):
pubmed: 29385708
Am J Physiol Cell Physiol. 2008 Jun;294(6):C1509-20
pubmed: 18367586
Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H513-22
pubmed: 22777418
FEBS J. 2021 Jan;288(2):452-470
pubmed: 32365408
J Cell Biol. 2015 Mar 30;208(7):869-80
pubmed: 25825515
Mitochondrion. 2022 Jul;65:45-55
pubmed: 35513218
Hum Mol Genet. 2015 Nov 15;24(22):6492-504
pubmed: 26358770
Cardiovasc Res. 2014 Jul 1;103(1):131-9
pubmed: 24788415
J Appl Physiol (1985). 2002 May;92(5):2177-86
pubmed: 11960972
Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15120-15125
pubmed: 27956640
Mol Cell Proteomics. 2012 Aug;11(8):467-77
pubmed: 22556278
Amino Acids. 2011 Mar;40(3):895-911
pubmed: 20798965
Nat Rev Cardiol. 2021 Jul;18(7):499-521
pubmed: 33619348
J Biol Chem. 1990 Jul 5;265(19):11377-81
pubmed: 2358467
Biochim Biophys Acta. 2010 Feb;1800(2):107-21
pubmed: 19664691
J Mol Cell Cardiol. 2007 Jan;42(1):177-85
pubmed: 17069847
Commun Biol. 2022 Apr 12;5(1):349
pubmed: 35414690
Am J Physiol Cell Physiol. 2007 Jan;292(1):C178-87
pubmed: 16899550
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1391-9
pubmed: 17573462
Biochem Biophys Res Commun. 2005 Apr 15;329(3):1155-61
pubmed: 15752775
Oxid Med Cell Longev. 2019 Nov 13;2019:6279313
pubmed: 31827688
Biochem Biophys Res Commun. 2002 Apr 26;293(1):207-12
pubmed: 12054585
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12222-6
pubmed: 11050244
J Cereb Blood Flow Metab. 2021 Jul;41(7):1523-1535
pubmed: 33153373
ACS Chem Biol. 2017 Aug 18;12(8):2030-2039
pubmed: 28541657
J Biol Chem. 2004 Aug 20;279(34):35313-9
pubmed: 15199059
Mol Cell Biochem. 2013 Jul;379(1-2):59-68
pubmed: 23543138
Cardiovasc Res. 2011 Feb 15;89(3):614-22
pubmed: 20978008
J Mol Cell Cardiol. 2006 Feb;40(2):303-12
pubmed: 16337959
Biochim Biophys Acta. 2016 May;1864(5):609-21
pubmed: 26854602
Mol Med Rep. 2023 Jan;27(1):
pubmed: 36367170
SAR QSAR Environ Res. 2013;24(9):733-52
pubmed: 23767808
Bioessays. 2018 Jul;40(7):e1800013
pubmed: 29709074
J Cell Physiol. 2019 Feb;234(2):1190-1207
pubmed: 30132875
Scand Cardiovasc J. 2013 Jun;47(3):168-74
pubmed: 23301939
Stem Cells. 2013 Apr;31(4):765-75
pubmed: 23335157
Biochem Biophys Res Commun. 2004 Jun 18;319(1):21-6
pubmed: 15158436
Int J Neurosci. 2023 Feb;133(2):194-200
pubmed: 33736564
J Biol Chem. 2012 Aug 24;287(35):30024-34
pubmed: 22745122
Redox Biol. 2015 Dec;6:260-271
pubmed: 26296072
Neurotherapeutics. 2021 Oct;18(4):2504-2517
pubmed: 34312767
J Biol Chem. 2016 Jan 29;291(5):2107-18
pubmed: 26598517
Am J Physiol Cell Physiol. 2006 Jan;290(1):C57-65
pubmed: 16107505
ACS Chem Biol. 2015 Jun 19;10(6):1392-7
pubmed: 25751766
Nat Commun. 2018 Jan 25;9(1):374
pubmed: 29371602
Redox Biol. 2021 Jul;43:101994
pubmed: 33964586
Shock. 2021 Nov 1;56(5):755-761
pubmed: 34652341
Basic Res Cardiol. 2020 Nov 25;115(6):71
pubmed: 33237428
Korean Circ J. 2015 May;45(3):234-41
pubmed: 26023312
J Biol Chem. 2019 Feb 15;294(7):2211-2231
pubmed: 30626734
Endocrinology. 2018 Aug 1;159(8):3120-3131
pubmed: 30010821
J Biol Chem. 2015 Dec 4;290(49):29141-53
pubmed: 26446791
Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1309-1320
pubmed: 29622561
Int J Mol Med. 2008 Dec;22(6):809-15
pubmed: 19020780
Glycobiology. 2006 Jan;16(1):22-8
pubmed: 16177265
Circ Res. 2020 May 8;126(10):e80-e96
pubmed: 32134364
Zhongguo Zhong Yao Za Zhi. 2023 Jun;48(12):3308-3316
pubmed: 37382015
Am J Physiol Cell Physiol. 2010 Jul;299(1):C139-47
pubmed: 20410435
PLoS One. 2011;6(8):e24021
pubmed: 21904602
Sci Rep. 2019 Dec 10;9(1):18751
pubmed: 31822776
Biochem Biophys Res Commun. 2007 Sep 21;361(2):414-20
pubmed: 17645866
J Am Coll Cardiol. 2017 Sep 19;70(12):1479-1492
pubmed: 28911512
Life Sci. 2019 Apr 1;222:1-12
pubmed: 30786250
Biochem Biophys Res Commun. 2006 Dec 1;350(4):1038-43
pubmed: 17045574
Nat Commun. 2023 Jun 8;14(1):3383
pubmed: 37291168
Biochem J. 1991 Aug 15;278 ( Pt 1):105-11
pubmed: 1883322
FEBS Lett. 2017 Sep;591(17):2648-2660
pubmed: 28696498
J Am Heart Assoc. 2018 Sep 4;7(17):e009634
pubmed: 30371162
Biochem J. 2001 Nov 15;360(Pt 1):179-88
pubmed: 11696006
Shock. 2007 Sep;28(3):345-52
pubmed: 17545939
Nature. 2013 Oct 17;502(7471):372-6
pubmed: 24077098
J Mol Neurosci. 2019 Oct;69(2):177-187
pubmed: 31201658
Shock. 2007 Apr;27(4):402-8
pubmed: 17414423
Cell. 2014 Mar 13;156(6):1179-1192
pubmed: 24630721
Diabetes. 1999 May;48(5):1101-7
pubmed: 10331416
JPEN J Parenter Enteral Nutr. 2008 Jul-Aug;32(4):371-6
pubmed: 18596307