Insights into Molecular Diversity within the FUS/EWS/TAF15 Protein Family: Unraveling Phase Separation of the N-Terminal Low-Complexity Domain from RNA-Binding Protein EWS.

Humans RNA-Binding Protein EWS / metabolism RNA-Binding Protein FUS / metabolism Phase Separation Sarcoma, Ewing / genetics Proteins / metabolism Tyrosine TATA-Binding Protein Associated Factors / genetics

Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
27 Mar 2024
Historique:
medline: 28 3 2024
pubmed: 16 3 2024
entrez: 16 3 2024
Statut: ppublish

Résumé

The FET protein family, comprising FUS, EWS, and TAF15, plays crucial roles in mRNA maturation, transcriptional regulation, and DNA damage response. Clinically, they are linked to Ewing family tumors and neurodegenerative diseases such as amyotrophic lateral sclerosis. The fusion protein EWS::FLI1, the causative mutation of Ewing sarcoma, arises from a genomic translocation that fuses a portion of the low-complexity domain (LCD) of EWS (EWS

Identifiants

DOI: 10.1021/jacs.3c12034 PMID: 38492239
pubmed: 38492239
doi: 10.1021/jacs.3c12034
doi:

Substances chimiques

RNA-Binding Protein EWS 0
RNA-Binding Protein FUS 0
Proteins 0
Tyrosine 42HK56048U
TAF15 protein, human 0
TATA-Binding Protein Associated Factors 0
FUS protein, human 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8071-8085

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM136917
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM153388
Pays : United States

Commentaires et corrections

Type : UpdateOf

Auteurs

Courtney N Johnson (CN)

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
ORCID: 0000-0003-4008-3480

Kandarp A Sojitra (KA)

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States.

Erich J Sohn (EJ)

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
ORCID: 0000-0001-5908-0912

Alma K Moreno-Romero (AK)

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.

Antoine Baudin (A)

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
ORCID: 0000-0002-1390-1196

Xiaoping Xu (X)

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.

Jeetain Mittal (J)

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843, United States.
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Interdisciplinary Graduate Program in Genetics and Genomics, Texas A&M University, College Station, Texas 77843, United States.
ORCID: 0000-0002-9725-6402

David S Libich (DS)

Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
ORCID: 0000-0001-6492-2803

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insights into Molecular Diversity within the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › Protéine EWS de liaison à l'ARN › Insights into Molecular Diversity within the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines à motif de reconnaissance de l'ARN › Ribonucléoprotéines nucléaires hétérogènes › Protéine FUS de liaison à l'ARN › Insights into Molecular Diversity within the...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu conjonctif et des tissus mous › Sarcomes › Ostéosarcome › Sarcome d'Ewing › Insights into Molecular Diversity within the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Insights into Molecular Diversity within the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Tyrosine › Insights into Molecular Diversity within the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs généraux de transcription › Facteurs associés à la protéine de liaison à la boite TATA › Insights into Molecular Diversity within the...