Synergizing structure and function: Cinnamoyl hydroxamic acids as potent urease inhibitors.
Interaction mechanism
Urease inhibitor
α,β-unsaturated hydroxamic acid
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
07 Mar 2024
07 Mar 2024
Historique:
received:
27
12
2023
revised:
16
02
2024
accepted:
27
02
2024
medline:
18
3
2024
pubmed:
18
3
2024
entrez:
17
3
2024
Statut:
aheadofprint
Résumé
The current investigation encompasses the structural planning, synthesis, and evaluation of the urease inhibitory activity of a series of molecular hybrids of hydroxamic acids and Michael acceptors, delineated from the structure of cinnamic acids. The synthesized compounds exhibited potent urease inhibitory effects, with IC
Identifiants
pubmed: 38493635
pii: S0045-2068(24)00152-4
doi: 10.1016/j.bioorg.2024.107247
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
107247Informations de copyright
Copyright © 2024 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.