Laparoscopic versus Vaginal Uterosacral Ligament Suspension in women with pelvic organ prolapse. A systematic review and meta-analysis of the literature.

Uterosacral ligament suspension (USLS) is one of the most frequently used operations for the restoration of apical support in women with uterovaginal prolapse. However, existing studies are inconclusive as to whether and which surgical access route is superior. The aim of the present meta-analysis is tentatively to compare the efficiency and the postoperative complications of laparoscopic uterosacral ligament suspension (L-USLS) and vaginal uterosacral ligament suspension (V-USLS), highlighting that current evidence remains inconclusive regarding the superiority of either surgical access route. We performed a systematic literature review of 5 major databases (Medline, Scopus, Google Scholar Cochrane Central Register of Controlled Trials and Clinicaltrials.gov) from inception till April 2023. No language restrictions were applied. All comparative studies that compared L-USLS and V-USLS for the management of women with uterovaginal prolapse were included. Data from 6 retrospective cohort studies on 856 patients were extracted and analyzed. The methodological quality of the included studies was assessed using the Risk Of Bias In Non-Randomized Studies of Interventions (ROBINS-I) tool and ranged between moderate to serious. The pooled results suggest that L-USLS was associated with a potentially decreased incidence of ureteral compromise (OR, 0.19; 95% CI 0.04 to 0.89; p = .04) and seemingly lower objective (OR 0.47; 95% CI 0.23 to 0.97; p = .04) and subjective recurrence rates (OR 0.46; 95% CI 0.23 to 0.92; p = .03). There were no significant differences between the rates of postoperative pain from USLS sutures, postoperative pelvic hematomas, the suture exposure/granulation tissue formation, and the prolapse recurrence retreatment among the two groups. The present meta-analysis indicates that L-USLS is possibly associated with significantly fewer ureteral compromise rates and decreased subjective and objective recurrences rates compared to V-USLS. Nevertheless, given the limitations in data quality and heterogeneity of the included studies, these findings should be interpreted with caution. Large-scale randomized studies are essential to more definitively determine the relative merits of the laparoscopic versus vaginal approach.

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