Sortilin in biliary epithelial cells promotes ductular reaction and fibrosis during cholestatic injury.
Cholestatic liver injury
Leukemia inhibitory factor receptor
Sortilin
ductular reaction
fibrosis
Journal
The American journal of pathology
ISSN: 1525-2191
Titre abrégé: Am J Pathol
Pays: United States
ID NLM: 0370502
Informations de publication
Date de publication:
15 Mar 2024
15 Mar 2024
Historique:
received:
11
09
2023
revised:
03
01
2024
accepted:
29
01
2024
medline:
18
3
2024
pubmed:
18
3
2024
entrez:
17
3
2024
Statut:
aheadofprint
Résumé
Cholestatic injuries are accompanied by a ductular reaction, initiated by proliferation and activation of biliary epithelial cells (BEC), leading to fibrosis. Sortilin (Sort1) facilitates IL-6 secretion and leukemia inhibitory factor (LIF) signaling. This study investigated the interplay between sortilin, IL-6 and LIF in cholestatic injury-induced ductular reaction, morphogenesis of new ducts and fibrosis. Cholestatic injury was induced by bile duct ligation (BDL) in WT and Sort1
Identifiants
pubmed: 38493927
pii: S0002-9440(24)00087-7
doi: 10.1016/j.ajpath.2024.01.023
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.