Engagement, initiation, and retention in medication treatment for opioid use disorder among young adults: A narrative review of challenges and opportunities.

Opioid Use Disorder (OUD) is a catastrophic public health problem for young adults (YAs) and their families. While medication for OUD (MOUD) is safe, effective, and recognized as the standard of care, its' uptake and success have been limited in YAs compared to older adults. This narrative review summarizes the existing literature and highlights select studies regarding barriers to YA MOUD, potential explanations for those barriers, and strategies to overcome them. Barriers are prominent along the entire cascade of care, including: treatment engagement and entry, MOUD initiation, and MOUD retention. Hypothesized explanations for barriers include: developmental vulnerability, inadequate treatment system capacity, stigma against MOUD, among others. Interventions to address barriers include: promotion of family involvement, increasing provider capacity, integration of MOUD into primary care, assertive outreach, and others. Integrating an adapted version of family coaching from the Community Reinforcement Approach and Family Training (CRAFT) and other models into YA MOUD treatment serves as an example of an emerging novel practice that holds promise for broadening the funnel of engagement in treatment and initiation of MOUD, and enhancing treatment outcomes. This and other developmentally-informed approaches should be evaluated as part of a high-priority clinical and research agenda for improving OUD treatment for YAs.

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Déclaration de conflit d'intérêts

Declaration of competing interest Dr. Fishman has been a consultant for Indivior, Alkermes, Drug Delivery LLC, Nirsum Labs. Dr. Marsch is affiliated with Square2 Systems Inc. and is a consultant for Boehringer Ingelheim and Click Therapeutics. These relationships are managed by her employer, Dartmouth College. Dr. Wenzel, Dr. Subramaniam, Dr. Levy, Dr. Borodovsky, Gauthier, McLeman, Fredyma, and Murray, have no financial or personal interests to declare. This manuscript reflects the views of the authors and may not reflect the opinions, views, and official policy or position of the U.S. Department of Health and Human Services or any of its affiliated institutions or agencies. Dr. Subramaniam was substantially involved in this project, consistent with her role as Scientific Officer in the CTN grants. She has no financial or personal interests to declare.