When to randomize patients in a randomized controlled trial?

Journal

Fertility and sterility
ISSN: 1556-5653
Titre abrégé: Fertil Steril
Pays: United States
ID NLM: 0372772

Informations de publication

Date de publication:
15 Mar 2024
Historique:
received: 12 03 2024
accepted: 12 03 2024
medline: 18 3 2024
pubmed: 18 3 2024
entrez: 17 3 2024
Statut: aheadofprint

Résumé

The timing of randomization should be carefully considered in the context of each trial as it has implications for the particular research question answered. In the majority of instances, randomization should be delayed until as close as practically possible to the moment of intervention. In some cases, early randomization may offer certain advantages, but trialists should balance these, including any administrative complexity or inconvenience, against the risk of avoidable protocol violations and avoidable dropout.

Identifiants

DOI: 10.1016/j.fertnstert.2024.03.008 PMID: 38494103
pubmed: 38494103
pii: S0015-0282(24)00179-1
doi: 10.1016/j.fertnstert.2024.03.008
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Sarah Lensen (S)

Department of Obstetrics and Gynaecology, Royal Women's Hospital, University of Melbourne, Melbourne, Australia.

Matthew R Sydes (MR)

University College London, London, UK.

Alex Polyakov (A)

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Australia, Reproductive Biology Unit, Royal Women's Hospital, Melbourne, Australia.

Jack Wilkinson (J)

Centre for Biostatistics, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Classifications MeSH