Overview of treatment strategies in paraneoplastic neurological syndromes.

Cerebellar degeneration Cyclophosphamide Encephalitis Immunotherapy Intravenous immunoglobulins Lambert-Eaton myasthenic syndrome Neuronopathy Opsoclonus-myoclonus Paraneoplastic neurological syndrome Plasma exchange Rituximab Stiff-person syndrome Tumor treatment

Journal

Handbook of clinical neurology
ISSN: 0072-9752
Titre abrégé: Handb Clin Neurol
Pays: Netherlands
ID NLM: 0166161

Informations de publication

Date de publication:
2024
Historique:
medline: 18 3 2024
pubmed: 18 3 2024
entrez: 17 3 2024
Statut: ppublish

Résumé

Treatment strategies in paraneoplastic neurological syndromes rely on the three pillars of tumor treatment, immunotherapy, and symptomatic treatment, the first one being by far the most important in the majority of patients and syndromes. Classically, antibodies against extracellular antigens are directly pathogenic, and patients with these syndromes are more responsive to immunomodulatory or immunosuppressive treatments than the ones with antibodies against intracellular targets. This chapter first discusses some general principles of tumor treatment and immunotherapy, followed by a closer look at specific treatment options for different clinical syndromes, focusing on symptomatic treatments.

Identifiants

pubmed: 38494299
pii: B978-0-12-823912-4.00015-3
doi: 10.1016/B978-0-12-823912-4.00015-3
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

97-112

Informations de copyright

Copyright © 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.

Auteurs

Jeroen Kerstens (J)

Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.

Maarten J Titulaer (MJ)

Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: m.titulaer@erasmusmc.nl.

Classifications MeSH