Competitive fungal commensalism mitigates candidiasis pathology.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
06 May 2024
06 May 2024
Historique:
received:
14
09
2023
revised:
17
01
2024
accepted:
14
02
2024
medline:
18
3
2024
pubmed:
18
3
2024
entrez:
18
3
2024
Statut:
ppublish
Résumé
The mycobiota are a critical part of the gut microbiome, but host-fungal interactions and specific functional contributions of commensal fungi to host fitness remain incompletely understood. Here, we report the identification of a new fungal commensal, Kazachstania heterogenica var. weizmannii, isolated from murine intestines. K. weizmannii exposure prevented Candida albicans colonization and significantly reduced the commensal C. albicans burden in colonized animals. Following immunosuppression of C. albicans colonized mice, competitive fungal commensalism thereby mitigated fatal candidiasis. Metagenome analysis revealed K. heterogenica or K. weizmannii presence among human commensals. Our results reveal competitive fungal commensalism within the intestinal microbiota, independent of bacteria and immune responses, that could bear potential therapeutic value for the management of C. albicans-mediated diseases.
Identifiants
pubmed: 38497819
pii: 276637
doi: 10.1084/jem.20231686
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israeli Science Foundation
ID : 696/21
Organisme : Weizmann Institute
Organisme : Morris Kahn Institute for Human Immunology
Organisme : Henry H. Drake Professorial Chair of Immunology
Organisme : Deutsche Forschungsgemeinschaft
ID : 390713860
Informations de copyright
© 2024 Sekeresova Kralova et al.