Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8

T cell exhaustion T cell memory development lactate transport monocarboxylate transporters (MCTs) virus latency

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
26 Mar 2024
Historique:
medline: 19 3 2024
pubmed: 19 3 2024
entrez: 18 3 2024
Statut: ppublish

Résumé

Lactate-proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus-specific CD8

Identifiants

DOI: 10.1073/pnas.2306763121 PMID: 38498711
pubmed: 38498711
doi: 10.1073/pnas.2306763121
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2306763121

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Stefania D'Aria (S)

Institute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, Belgium.
ORCID: 0000-0003-4693-4565

Céline Maquet (C)

Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - Fundamental and Applied Research for Animals & Health Research Unit, University of Liège, Liège 4000, Belgium.
ORCID: 0000-0003-4009-0744

Shuang Li (S)

Institute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, Belgium.

Suveera Dhup (S)

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels 1200, Belgium.

Anouk Lepez (A)

Immunobiology Laboratory, Faculty of Sciences, Université libre de Bruxelles, Gosselies 6041, Belgium.
ORCID: 0000-0002-9612-0706

Arnaud Kohler (A)

Institute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, Belgium.

Vincent F Van Hée (VF)

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels 1200, Belgium.

Rajesh K Dadhich (RK)

Pole of Pharmacology, Institut de Recherche Expérimentale et Clinique, Université catholique de Louvain, Brussels 1200, Belgium.

Marine Frenière (M)

Institute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, Belgium.

Fabienne Andris (F)

Immunobiology Laboratory, Faculty of Sciences, Université libre de Bruxelles, Gosselies 6041, Belgium.
ORCID: 0000-0002-8644-1020

Ivan Nemazanyy (I)

Plateforme d'étude du métabolisme, Institut Necker, Inserm US 24 - CNRS UMS 3633, Faculté de Médecine Paris Descartes, Paris 75015, France.
ORCID: 0000-0001-8080-839X

Pierre Sonveaux (P)

WEL Research Institute, Welbio Department, Wavre 1300, Belgium.
ORCID: 0000-0001-6484-8834

Bénédicte Machiels (B)

Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - Fundamental and Applied Research for Animals & Health Research Unit, University of Liège, Liège 4000, Belgium.

Laurent Gillet (L)

Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine - Fundamental and Applied Research for Animals & Health Research Unit, University of Liège, Liège 4000, Belgium.
ORCID: 0000-0002-1047-2525

Michel Y Braun (MY)

Institute for Medical Immunology, Faculty of Medicine, Université libre de Bruxelles, Gosselies 6041, Belgium.

Classifications MeSH