In vitro evaluation of PET radiotracers for imaging synaptic density, the acetylcholine transporter, AMPA-tarp-γ8 and muscarinic M4 receptors in Alzheimer's disease.
Alzheimer’s disease
Autoradiography
PET
SV2A
SynVesT-1
cholinergic
fluorine-18
glutamatergic
synaptic density
tritium
Journal
American journal of nuclear medicine and molecular imaging
ISSN: 2160-8407
Titre abrégé: Am J Nucl Med Mol Imaging
Pays: United States
ID NLM: 101564121
Informations de publication
Date de publication:
2024
2024
Historique:
received:
18
10
2023
accepted:
04
02
2024
medline:
19
3
2024
pubmed:
19
3
2024
entrez:
19
3
2024
Statut:
epublish
Résumé
Several therapeutics and biomarkers that target Alzheimer's disease (AD) are under development. Our clinical positron emission tomography (PET) research programs are interested in six radiopharmaceuticals to image patients with AD and related dementias, specifically [
Types de publication
Journal Article
Langues
eng
Pagination
1-12Informations de copyright
AJNMMI Copyright © 2024.
Déclaration de conflit d'intérêts
N.V. is a co-founder of MedChem Imaging, Inc., S.K. was an employee of Eisai Inc. when the work was undertaken, and A.C. and P.S. are currently employees of Eisai Inc.