Synthesis, biological activities, and molecular docking studies of triazolo[4,3-b]triazine derivatives as a novel class of α-glucosidase and α-amylase inhibitors.
diabetes
molecular docking
α-amylase
α-glucosidase
Journal
Archiv der Pharmazie
ISSN: 1521-4184
Titre abrégé: Arch Pharm (Weinheim)
Pays: Germany
ID NLM: 0330167
Informations de publication
Date de publication:
19 Mar 2024
19 Mar 2024
Historique:
revised:
12
02
2024
received:
29
10
2023
accepted:
13
02
2024
medline:
19
3
2024
pubmed:
19
3
2024
entrez:
19
3
2024
Statut:
aheadofprint
Résumé
In diabetes mellitus, amylase and glucosidase enzymes are the primary triggers. The main function of these enzymes is to break macromolecules into simple sugar units, which directly affect blood sugar levels by increasing blood permeability. To overcome this metabolic effect, there is a need for a potent and effective inhibitor capable of suppressing the enzymatic conversion of sugar macromolecules into their smaller units. Herein, we reported the discovery of a series of substituted triazolo[4,3-b][1,2,4]triazine derivatives as α-glucosidase and α-amylase inhibitors. All target compounds demonstrated significant inhibitory activities against α-glucosidase and α-amylase enzymes compared with acarbose as the positive control. The most potent compound 10k, 2-[(6-phenyl-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl)thio]-N-[4-(trifluoromethyl)phenyl]acetamide, demonstrated IC
Identifiants
pubmed: 38501879
doi: 10.1002/ardp.202300628
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2300628Subventions
Organisme : National Institute for Medical Research Development
ID : 53816
Organisme : TUBITAK ULAKBIM
Organisme : High Performance and Grid Computing Center
Organisme : Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP)
ID : RGD-020
Informations de copyright
© 2024 Deutsche Pharmazeutische Gesellschaft.
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