Glucuronic acid confers colonization advantage to enteric pathogens.
Citrobacter rodentium
enteric pathogens
glucuronic acid
microbiota glucuronidase
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
26 Mar 2024
26 Mar 2024
Historique:
medline:
19
3
2024
pubmed:
19
3
2024
entrez:
19
3
2024
Statut:
ppublish
Résumé
Glucuronidation is a detoxification process to eliminate endo- and xeno-biotics and neurotransmitters from the host circulation. Glucuronosyltransferase binds these compounds to glucuronic acid (GlcA), deactivating them and allowing their elimination through the gastrointestinal (GI) tract. However, the microbiota produces β-glucuronidases that release GlcA and reactivate these compounds. Enteric pathogens such as enterohemorrhagic
Identifiants
pubmed: 38502690
doi: 10.1073/pnas.2400226121
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2400226121Subventions
Organisme : HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID)
ID : AI053067
Organisme : HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID)
ID : AI154597
Organisme : HHS | NIH | NIAID | Division of Intramural Research (DIR, NIAID)
ID : AI155398
Déclaration de conflit d'intérêts
Competing interests statement:The authors declare no competing interest.