Unlocking potential: the role of the electron transport chain in immunometabolism.
adaptive immunity
electron transport chain
immunometabolism
innate immunity
mitochondria
reactive oxygen species
respiratory complexes
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
18 Mar 2024
18 Mar 2024
Historique:
received:
13
02
2024
revised:
20
02
2024
accepted:
23
02
2024
medline:
20
3
2024
pubmed:
20
3
2024
entrez:
19
3
2024
Statut:
aheadofprint
Résumé
The electron transport chain (ETC) couples electron transfer with proton pumping to generate ATP and it also regulates particular innate and adaptive immune cell function. While NLRP3 inflammasome activation was initially linked to reactive oxygen species (ROS) produced from Complexes I and III, recent research suggests that an intact ETC fueling ATP is needed. Complex II may be responsible for Th1 cell proliferation and in some cases, effector cytokine production. Complex III is required for regulatory T (Treg) cell function, while oxidative phosphorylation (OXPHOS) and Complexes I, IV, and V sustain proliferation and antibody production in B lymphocytes, with OXPHOS also being required for B regulatory (Breg) cell function. Despite challenges, the ETC shows therapeutic targeting potential for immune-related diseases and in immuno-oncology.
Identifiants
pubmed: 38503657
pii: S1471-4906(24)00027-9
doi: 10.1016/j.it.2024.02.002
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.