Preconception opioids interact with mouse strain to alter morphine withdrawal in the next generation.

Corticosterone Glucose regulation Hypothalamic–pituitary–adrenal axis Morphine Naloxone-precipitated withdrawal

Journal

Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025

Informations de publication

Date de publication:
19 Mar 2024
Historique:
received: 02 10 2023
accepted: 10 03 2024
medline: 20 3 2024
pubmed: 20 3 2024
entrez: 20 3 2024
Statut: aheadofprint

Résumé

Transgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenetic modifications triggered by female opioid exposure, even when that exposure ends several weeks prior to pregnancy, has significant ramifications for their future offspring. The current study compares two mouse strains with well-established genetic variation in their response to mu opioid receptor agonists, C57BL/6J (BL6) and 129S1/svlmJ (129) to determine whether genetic background modifies the impact of preconception opioid exposure. Adolescent females from both strains were injected daily with morphine for a total of 10 days using an increasing dosing regimen with controls receiving saline. Several weeks after their final injection, aged-matched BL6 and 129 morphine (Mor-F0) or saline (Sal-F0) females were mated with drug naïve males to generate Mor-F1 and Sal-F1 offspring, respectively. As adults, F1 mice were made morphine dependent using thrice daily morphine injections for 4 days. On day 5, mice were administered either saline or morphine followed 3 h later by naloxone. Behavioral and physiological signs of withdrawal were then measured. Regardless of strain or sex, morphine-dependent Mor-F1 mice had significantly lower levels of withdrawal-induced corticosterone but significantly higher glucose levels when compared to Sal-F1 controls. In contrast, both strain- and preconception opioid exposure effects on physical signs of morphine dependence were observed.

Identifiants

DOI: 10.1007/s00213-024-06574-0 PMID: 38503843
pubmed: 38503843
doi: 10.1007/s00213-024-06574-0
pii: 10.1007/s00213-024-06574-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIDA NIH HHS
ID : DA025674
Pays : United States

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Anika Toorie (A)

Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA.
Department of Biology, Rhode Island College, 600 Mount Pleasant Ave, Providence, RI, USA.

Claire Davidson Hall (CD)

Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA.

Fair M Vassoler (FM)

Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA.

Gary Peltz (G)

Department of Anesthesia, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA, USA.

Elizabeth M Byrnes (EM)

Department of Comparative Pathobiology, Cummings School of Veterinary Medicine at Tufts University, 200 Westboro Rd, North Grafton, MA, USA. elizabeth.byrnes@tufts.edu.
ORCID: 0000-0002-8458-7712

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