Allogeneic hematopoietic stem-cell transplantation for patients with Richter transformation: a retrospective study on behalf of the Chronic Malignancies Working Party of the EBMT.


Journal

Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459

Informations de publication

Date de publication:
19 Mar 2024
Historique:
received: 23 11 2023
accepted: 22 02 2024
revised: 20 02 2024
medline: 20 3 2024
pubmed: 20 3 2024
entrez: 20 3 2024
Statut: aheadofprint

Résumé

Management of Richter transformation (RT) is particularly challenging, with survival estimates <1 year. We report on outcomes of 66 RT patients undergoing allogeneic-HCT (allo-HCT) between 2008 and 2018 registered with the EBMT. Median age at allo-HCT was 56.2 years (interquartile range (IQR), 51.3-63.1). Median time from RT to allo-HCT was 6.9 months (IQR, 4.9-11) and 28 (42.4%) were in complete remission (CR). The majority underwent reduced intensity conditioning (66.2%) using peripheral blood derived stem cells. Eighteen (27.3%) patients had a matched sibling donor, 24 (36.4%) a matched unrelated donor and the remaining were mismatched. Median follow-up was 6.6 years; 1- and 3- year overall and progression free survival (PFS) (95% CI) was 65% (54-77) and 39% (27-51) and 53% (41-65) and 29% (18-40), respectively. Patients in CR at time of allo-HCT had significantly better 3-year PFS (39% vs. 21%, p = 0.032). Cumulative incidences of grade II-IV acute graft versus host disease (GVHD) at day +100 was 41% (95% CI 29-53) and chronic GVHD at 3 years was 53% (95% CI 41-65). High rates of non-relapse mortality (NRM) were observed; 38% (95% CI, 26-50) at 3 years. Although potentially curative, approaches to reduce considerable NRM and chronic GVHD rates are required.

Identifiants

pubmed: 38503942
doi: 10.1038/s41409-024-02256-9
pii: 10.1038/s41409-024-02256-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Romain Guièze (R)

CHU Estaing, Clermont-Ferrand University Hospital, Clermont-Ferrand, France. rguieze@chu-clermontferrand.fr.

Diderik-Jan Eikema (DJ)

EBMT Statistical Unit, Leiden, The Netherlands.

Linda Koster (L)

EBMT Leiden Study Unit, Leiden, The Netherlands.

Johannes Schetelig (J)

University Hospital Dresden, Dresden, Germany.

Henrik Sengeloev (H)

Rigshospitalet, Copenhagen, Denmark.

Jakob Passweg (J)

University Hospital Basel, Basel, Switzerland.

Jürgen Finke (J)

University of Freiburg, Freiburg, Germany.

Mutlu Arat (M)

Demiroglu Bilim University Istanbul Florence Nightingale Hospital, Istanbul, Turkey.

Annoek E C Broers (AEC)

Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Friedrich Stölzel (F)

Department of Medicine II, Division for Stem Cell Transplantation and Cellular Immunotherapy, University Hospital Schleswig-Holstein Kiel, Kiel University, Kiel, Germany.

Jenny Byrne (J)

Nottingham University, Nottingham, UK.

Cristina Castilla-Llorente (C)

Gustave Roussy Cancer Campus, Villejuif, France.

Peter Dreger (P)

University of Heidelberg, Heidelberg, Germany.

Matthias Eder (M)

Hannover Medical School, Hannover, Germany.

Tobias Gedde-Dahl (T)

Oslo University Hospital, Rikshospitalet, Oslo, Norway.

Nicolaus Kröger (N)

University Hospital Eppendorf, Hamburg, Germany.

Josep Maria Ribera Santasusana (JM)

ICO-Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Deborah Richardson (D)

Southampton General Hospital, Southampton, UK.

Alessandro Rambaldi (A)

ASST Papa Giovanni XXIII, Bergamo, Italy.

Lucrecia Yañez (L)

Hospital U. Marqués de Valdecilla, Santander, Spain.

Michel Van Gelder (M)

Maastricht University Medical Center, Maastricht, The Netherlands.

Joanna Drozd-Sokolowska (J)

University Clinical Centre, Medical University of Warsaw, Warsaw, Poland.

Kavita Raj (K)

University College London Hospitals NHS Trust London, London, UK.

Ibrahim Yakoub-Agha (I)

CHU de Lille, Univ Lille, INSERM U1286, Infinite, 59000, Lille, France.

Olivier Tournilhac (O)

CHU Estaing, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.

Donal P McLornan (DP)

University College London Hospitals NHS Trust London, London, UK.

Classifications MeSH