Synthesis of Enantiopure Sulfoxides by Concurrent Photocatalytic Oxidation and Biocatalytic Reduction.

The concurrent operation of chemical and biocatalytic reactions in one pot is still a challenging task, and, in particular for chemical photocatalysts, examples besides simple cofactor recycling systems are rare. However, especially due to the complementary chemistry that the two fields of catalysis promote, their combination in one pot has the potential to unlock intriguing, unprecedented overall reactivities. Herein we demonstrate a concurrent biocatalytic reduction and photocatalytic oxidation process. Specifically, the enantioselective biocatalytic sulfoxide reduction using ( The power of biocatalysis and photocatalysis was combined in one pot for a concurrent reduction–oxidation sequence to gain access to enantiopure sulfoxides. In a cyclic deracemization process the enantioselective biocatalytic reduction is followed by a non‐stereoselective light‐dependent oxidation to yield the desired target compounds in >99 %

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© 2022 The Authors. Angewandte Chemie published by Wiley-VCH GmbH.

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The authors declare no conflict of interest.