Pre-proenkephalin 1 is Downregulated Under Unloading and is Involved in Osteoblast Biology.
Mechanical unloading
Osteoblast differentiation
Pre-proenkephalin1 (Penk1)
Journal
Calcified tissue international
ISSN: 1432-0827
Titre abrégé: Calcif Tissue Int
Pays: United States
ID NLM: 7905481
Informations de publication
Date de publication:
20 Mar 2024
20 Mar 2024
Historique:
received:
09
09
2023
accepted:
20
02
2024
medline:
20
3
2024
pubmed:
20
3
2024
entrez:
20
3
2024
Statut:
aheadofprint
Résumé
Pre-proenkephalin 1 (Penk1) is a pro-neuropeptide that belongs to the typical opioid peptide's family, having analgesic properties. We previously found Penk1 to be the most downregulated gene in a whole gene profiling analysis performed in osteoblasts subjected to microgravity as a model of mechanical unloading. In this work, Penk1 downregulation was confirmed in the bones of two in vivo models of mechanical unloading: tail-suspended and botulinum toxin A (botox)-injected mice. Consistently, in the sera from healthy volunteers subjected to bed rest, we observed an inverse correlation between PENK1 and bed rest duration. These results prompted us to investigate a role for this factor in bone. Penk1 was highly expressed in mouse bone, but its global deletion failed to impact bone metabolism in vivo. Indeed, Penk1 knock out (Penk1
Identifiants
pubmed: 38506955
doi: 10.1007/s00223-024-01199-z
pii: 10.1007/s00223-024-01199-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agenzia Spaziale Italiana
ID : N.2019-11-U.0
Informations de copyright
© 2024. The Author(s).
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