Synthesis and in vitro antitumor activity of galactosamine-docetaxel conjugates.
conjugate
diselenide
docetaxel
galactosamine
hepatoma
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
Mar 2024
Mar 2024
Historique:
revised:
29
02
2024
received:
13
11
2023
accepted:
12
03
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
20
3
2024
Statut:
ppublish
Résumé
Docetaxel (DTX) is a semi-synthetic analogue of paclitaxel which has attracted extensive attention in the treatment of cancer. However, the current clinically used DTX formulations display low tumor targeting ability, leading to unsatisfactory therapeutic outcomes with adverse effects, which poses significant challenges to the clinical application. In this study, three galactosamine (Gal) and docetaxel conjugates with different linkers were synthesized, namely DTX-(suc-Gal)
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14511Subventions
Organisme : Key Research and Development Program of Changzhou
ID : CJ20210030
Informations de copyright
© 2024 John Wiley & Sons Ltd.
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