Pediatric perforated appendicitis diagnosis based on the C-reactive protein/prealbumin ratio.
Biomarker
C-reactive protein
Early intervention
Odds ratio
Pediatric
Perforated appendicitis
Prealbumin
Predictor
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 Mar 2024
20 Mar 2024
Historique:
received:
10
12
2023
accepted:
20
02
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
21
3
2024
Statut:
epublish
Résumé
Pediatric perforated appendicitis, prone to multiple complications, necessitates identifying potential serum biomarkers for early diagnosis and intervention. A cross-sectional study was conducted on patients under 16 with acute appendicitis, admitted to Hainan Women and Children's Medical Center from January 2019 to July 2023. The patients were categorized into perforated and non-perforated groups. Among the 313 included patients, 106 (33.87%, 95% CI 28.59-39.14%) developed perforation. The C-reactive protein to prealbumin ratio (CPA) showed a significant difference between the perforated and non-perforated groups [6.63 (2.9-13.02) vs. 0.7 (0.11-2.18), p < 0.001]. The AUC of CPA on the ROC curve was 0.691 (95% CI 0.513-0.869, p = 0.084) in patients under 4. In patients aged 4-9, the sensitivity of CPA > 3 predicting perforation was 76.2%, with a specificity of 81.6%, and an AUC of 0.816 (95% CI 0.747-0.886, p < 0.001). For patients aged 9-16, the sensitivity of CPA > 2.2 predicting perforation was 85%, with a specificity of 85.7%, and an AUC of 0.919 (95% CI 0.859-0.979, p < 0.001). CPA > 3 and CPA > 2.2 can predict perforated appendicitis in patients aged 4-9 and 9-16, respectively.
Identifiants
pubmed: 38509094
doi: 10.1038/s41598-024-55108-3
pii: 10.1038/s41598-024-55108-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6729Subventions
Organisme : Hainan Provincial Clinical Medical Center
ID : QWYH202175
Organisme : Hainan Provincial Clinical Medical Center
ID : QWYH202175
Organisme : Hainan Provincial Clinical Medical Center
ID : QWYH202175
Organisme : Hainan Provincial Clinical Medical Center
ID : QWYH202175
Organisme : Hainan Provincial Clinical Medical Center
ID : QWYH202175
Informations de copyright
© 2024. The Author(s).
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