Sulfide oxidation promotes hypoxic angiogenesis and neovascularization.
Journal
Nature chemical biology
ISSN: 1552-4469
Titre abrégé: Nat Chem Biol
Pays: United States
ID NLM: 101231976
Informations de publication
Date de publication:
20 Mar 2024
20 Mar 2024
Historique:
received:
13
03
2023
accepted:
20
02
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
21
3
2024
Statut:
aheadofprint
Résumé
Angiogenic programming in the vascular endothelium is a tightly regulated process for maintaining tissue homeostasis and is activated in tissue injury and the tumor microenvironment. The metabolic basis of how gas signaling molecules regulate angiogenesis is elusive. Here, we report that hypoxic upregulation of ·NO in endothelial cells reprograms the transsulfuration pathway to increase biogenesis of hydrogen sulfide (H
Identifiants
pubmed: 38509349
doi: 10.1038/s41589-024-01583-8
pii: 10.1038/s41589-024-01583-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R35GM130183
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01CA248160
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01CA148828
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R01CA245546
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.
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