Assessment of the axial resolution of a compact gamma camera with coded aperture collimator.
Axial resolution
Coded aperture
Compact gamma camera
Image reconstruction
Intraoperative imaging
Radioguided surgery
Timepix3
Journal
EJNMMI physics
ISSN: 2197-7364
Titre abrégé: EJNMMI Phys
Pays: Germany
ID NLM: 101658952
Informations de publication
Date de publication:
21 Mar 2024
21 Mar 2024
Historique:
received:
04
09
2023
accepted:
06
03
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
21
3
2024
Statut:
epublish
Résumé
Handheld gamma cameras with coded aperture collimators are under investigation for intraoperative imaging in nuclear medicine. Coded apertures are a promising collimation technique for applications such as lymph node localization due to their high sensitivity and the possibility of 3D imaging. We evaluated the axial resolution and computational performance of two reconstruction methods. An experimental gamma camera was set up consisting of the pixelated semiconductor detector Timepix3 and MURA mask of rank 31 with round holes of 0.08 mm in diameter in a 0.11 mm thick Tungsten sheet. A set of measurements was taken where a point-like gamma source was placed centrally at 21 different positions within the range of 12-100 mm. For each source position, the detector image was reconstructed in 0.5 mm steps around the true source position, resulting in an image stack. The axial resolution was assessed by the full width at half maximum (FWHM) of the contrast-to-noise ratio (CNR) profile along the z-axis of the stack. Two reconstruction methods were compared: MURA Decoding and a 3D maximum likelihood expectation maximization algorithm (3D-MLEM). While taking 4400 times longer in computation, 3D-MLEM yielded a smaller axial FWHM and a higher CNR. The axial resolution degraded from 5.3 mm and 1.8 mm at 12 mm to 42.2 mm and 13.5 mm at 100 mm for MURA Decoding and 3D-MLEM respectively. Our results show that the coded aperture enables the depth estimation of single point-like sources in the near field. Here, 3D-MLEM offered a better axial resolution but was computationally much slower than MURA Decoding, whose reconstruction time is compatible with real-time imaging.
Identifiants
pubmed: 38509411
doi: 10.1186/s40658-024-00631-5
pii: 10.1186/s40658-024-00631-5
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30Subventions
Organisme : Zentrales Innovationsprogramm Mittelstand (ZIM)
ID : KK5044701BS0
Informations de copyright
© 2024. The Author(s).
Références
Farnworth AL, Bugby SL. Intraoperative gamma cameras: a review of development in the last decade and future outlook. J Imaging. 2023;9(5):102. https://doi.org/10.3390/jimaging9050102 .
doi: 10.3390/jimaging9050102
pubmed: 37233321
pmcid: 10219460
Peterson TE, Furenlid LR. SPECT detectors: the anger camera and beyond. Phys Med Biol. 2011. https://doi.org/10.1088/0031-9155/56/17/R01 .
doi: 10.1088/0031-9155/56/17/R01
pubmed: 21852723
pmcid: 3178965
Fujii H, Idoine JD, Gioux S, Accorsi R, Slochower DR, Lanza RC, et al. Optimization of coded aperture radioscintigraphy for sentinel lymph node mapping. Mol Imag Biol. 2012;14(2):173–82. https://doi.org/10.1007/s11307-011-0494-2 .
doi: 10.1007/s11307-011-0494-2
Ozkan E, Eroglu A. The utility of intraoperative handheld gamma camera for detection of sentinel lymph nodes in melanoma. Nucl Med Mol Imaging. 2015;49(4):318–20. https://doi.org/10.1007/s13139-015-0341-5 .
doi: 10.1007/s13139-015-0341-5
pubmed: 26550052
pmcid: 4630332
Kogler AK, Polemi AM, Nair S, Majewski S, Dengel LT, Slingluff CL, et al. Evaluation of camera-based freehand SPECT in preoperative sentinel lymph node mapping for melanoma patients. EJNMMI Res. 2020. https://doi.org/10.1186/s13550-020-00729-8 .
doi: 10.1186/s13550-020-00729-8
pubmed: 33175204
pmcid: 7658290
Massari R, Ucci A, Campisi C, Scopinaro F, Soluri A. A novel fully integrated handheld gamma camera. Nucl Instrum Methods Phys Res Sect A. 2016;832:271–8. https://doi.org/10.1016/j.nima.2016.06.124 .
doi: 10.1016/j.nima.2016.06.124
Fenimore EE. Coded aperture imaging: predicted performance of uniformly redundant arrays. Appl Opt. 1978;17(22):3562. https://doi.org/10.1364/ao.17.003562 .
doi: 10.1364/ao.17.003562
pubmed: 20204031
Cannon TM, Fenimore EE. Tomographical imaging using uniformly redundant arrays. Appl Opt. 1979;18(7):1052. https://doi.org/10.1364/AO.18.001052 .
doi: 10.1364/AO.18.001052
pubmed: 20208873
Accorsi R, Lanza RC. Near-field artifact reduction in planar coded aperture imaging. Appl Opt. 2001;40(26):4697. https://doi.org/10.1364/AO.40.004697 .
doi: 10.1364/AO.40.004697
pubmed: 18360511
Mu Z, Liu Y-H. Aperture collimation correction and maximum-likelihood image reconstruction for near-field coded aperture imaging of single photon emission computerized tomography. IEEE Trans Med Imaging. 2006;25(6):701–11. https://doi.org/10.1109/TMI.2006.873298 .
doi: 10.1109/TMI.2006.873298
pubmed: 16768235
Kaissas I, Papadimitropoulos C, Potiriadis C, Karafasoulis K, Loukas D, Lambropoulos CP. Imaging of spatially extended hot spots with coded apertures for intra-operative nuclear medicine applications. J Instrum. 2017;12(1):1–9. https://doi.org/10.1088/1748-0221/12/01/C01059 .
doi: 10.1088/1748-0221/12/01/C01059
Paradiso V, Amgarou K, de Lanaute NB, Bonnet F, Beltramello O, Liénard E. 3-D localization of radioactive hotspots via portable gamma cameras. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip. 2018;910(August):194–203. https://doi.org/10.1016/j.nima.2018.09.081 .
doi: 10.1016/j.nima.2018.09.081
Russo P, Di Lillo F, Corvino V, Frallicciardi PM, Sarno A, Mettivier G. CdTe compact gamma camera for coded aperture imaging in radioguided surgery. Phys Med. 2019;2020(69):223–32. https://doi.org/10.1016/j.ejmp.2019.12.024 .
doi: 10.1016/j.ejmp.2019.12.024
Mu Z, Dobrucki LW, Liu YH. SPECT imaging of 2-D and 3-D distributed sources with near-field coded aperture collimation: computer simulation and real data validation. J Med Biol Eng. 2016;36(1):32–43. https://doi.org/10.1007/s40846-016-0111-6 .
doi: 10.1007/s40846-016-0111-6
pubmed: 27069461
pmcid: 4791458
Ibraheem MH, Gamil M, Tantawy A, Talaat O, Boutrrus R, Gomaa MMM. The role of intra-operative mobile gamma camera and gamma probe in detection of sentinel lymph node in early stage breast cancer. J Cancer Sci Clin Ther. 2019;03(04):229–39. https://doi.org/10.26502/jcsct.5079037 .
doi: 10.26502/jcsct.5079037
Rozhkov V, Chelkov G, Hernández I, Ivanov O, Kozhevnikov D, Leyva A, et al. Visualization of radiotracers for SPECT imaging using a Timepix detector with a coded aperture. J Instrum. 2020;15(06):P06028–P06028. https://doi.org/10.1088/1748-0221/15/06/p06028 .
doi: 10.1088/1748-0221/15/06/p06028
Bertolucci E, Maiorino M, Mettivier G, Montesi MC, Russo P. Preliminary test of an imaging probe for nuclear medicine using hybrid pixel detectors. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip. 2002;487(1–2):193–201. https://doi.org/10.1016/S0168-9002(02)00965-8 .
doi: 10.1016/S0168-9002(02)00965-8
Russo P, Mettivier G. Method for measuring the focal spot size of an x-ray tube using a coded aperture mask and a digital detector. Med Phys. 2011;38(4):2099–115. https://doi.org/10.1118/1.3567503 .
doi: 10.1118/1.3567503
pubmed: 21626943
Gottesman SR, Fenimore EE. New family of binary arrays for coded aperture imaging. Appl Opt. 1989;28(20):4344. https://doi.org/10.1364/ao.28.004344 .
doi: 10.1364/ao.28.004344
pubmed: 20555874
Cieślak MJ, Gamage KAA, Glover R. Coded-aperture imaging systems: past, present and future development—a review. Radiat Meas. 2016;92:59–71. https://doi.org/10.1016/j.radmeas.2016.08.002 .
doi: 10.1016/j.radmeas.2016.08.002
Accorsi R, Celentano L, Laccetti P, Lanza RC, Marotta M, Mettivier G, et al. High-resolution 125I small animal imaging with a coded aperture and a hybrid pixel detector. IEEE Trans Nucl Sci. 2008;55(1):481–90. https://doi.org/10.1109/TNS.2007.909846 .
doi: 10.1109/TNS.2007.909846
Meißner T, Rozhkov V, Hesser J, Nahm W, Loew N. Quantitative comparison of planar coded aperture imaging reconstruction methods. J Instrum. 2023;18(01):P01006. https://doi.org/10.1088/1748-0221/18/01/P01006 . arXiv: 2204.14113 .
doi: 10.1088/1748-0221/18/01/P01006
Accorsi R, Gasparini F, Lanza RC. Optimal coded aperture patterns for improved SNR in nuclear medicine imaging. Nucl Instrum Methods Phys Res Sect A Accel Spectrom Detect Assoc Equip. 2001;474(3):273–84. https://doi.org/10.1016/S0168-9002(01)01326-2 .
doi: 10.1016/S0168-9002(01)01326-2
Buzug T. Algebraic and statistical reconstruction methods. In: Computed tomography. Berlin, Heidelberg: Springer; 2008. p. 201–240. Available from: http://link.springer.com/10.1007/978-3-540-39408-2_6 .
Schellingerhout D, Accorsi R, Mahmood U, Idoine J, Lanza RC, Weissleder R. Coded aperture nuclear scintigraphy: a novel small animal imaging technique. Mol Imaging. 2002;1(4):153535002002213. https://doi.org/10.1162/15353500200221362 .
doi: 10.1162/15353500200221362