Effects of melatonin against experimentally induced apical periodontitis in rats.
animal model
apical periodontitis
melatonin
micro‐CT
rat
Journal
Australian endodontic journal : the journal of the Australian Society of Endodontology Inc
ISSN: 1747-4477
Titre abrégé: Aust Endod J
Pays: Australia
ID NLM: 100888004
Informations de publication
Date de publication:
21 Mar 2024
21 Mar 2024
Historique:
revised:
17
01
2024
received:
24
09
2023
accepted:
10
03
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
21
3
2024
Statut:
aheadofprint
Résumé
Apical periodontitis is an inflammatory condition resulting from microbial invasion in the root canal system, causing periapical tissue destruction and bone resorption. This study investigated melatonin's effects, known for its antioxidant and anti-inflammatory properties, on experimentally induced apical periodontitis in rats. Three groups of rats were studied: control, apical periodontitis and apical periodontitis with melatonin treatment. Proinflammatory cytokines and enzyme levels in blood serum were measured, and micro-CT analysis assessed bone resorption. Results showed significantly elevated cytokines and enzyme levels in the apical periodontitis group compared to the control. However, in the melatonin-treated group, these levels were significantly reduced (p < 0.01-0.001). Micro-CT analysis indicated decreased periapical resorption cavity volume and surface area with melatonin treatment. This suggests that systemic melatonin administration can mitigate inflammation and reduce bone resorption in experimentally induced apical periodontitis in rats, potentially holding promise for human endodontic disease treatment pending further research.
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2024 Australian Society of Endodontology Inc.
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