Linking sarcopenia, brain structure and cognitive performance: a large-scale UK Biobank study.

T1-weighted MRI degenerative conditions ectopic fat mediator skeletal muscle

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2024
Historique:
received: 14 09 2023
revised: 15 12 2023
accepted: 06 03 2024
medline: 21 3 2024
pubmed: 21 3 2024
entrez: 21 3 2024
Statut: epublish

Résumé

Sarcopenia refers to age-related loss of muscle mass and function and is related to impaired somatic and brain health, including cognitive decline and Alzheimer's disease. However, the relationships between sarcopenia, brain structure and cognition are poorly understood. Here, we investigate the associations between sarcopenic traits, brain structure and cognitive performance. We included 33 709 UK Biobank participants (54.2% female; age range 44-82 years) with structural and diffusion magnetic resonance imaging, thigh muscle fat infiltration (

Identifiants

DOI: 10.1093/braincomms/fcae083 PMID: 38510210 PMC: PMC10953622
pubmed: 38510210
doi: 10.1093/braincomms/fcae083
pii: fcae083
pmc: PMC10953622
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcae083

Informations de copyright

© The Author(s) 2024. Published by Oxford University Press on behalf of the Guarantors of Brain.

Déclaration de conflit d'intérêts

O.A.A. has received a speaker's honorarium from Lundbeck, Sunovion, Otsuka and Janssen and is a consultant to Cortechs.ai. J.L. is an employee and shareholder of AMRA Medical AB and has received consulting honorarium/speaking fees from Eli Lilly and BioMarin. The remaining authors declare no conflict of interest.

Auteurs

Tiril P Gurholt (TP)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
ORCID: 0000-0002-1272-7616

Miguel Germán Borda (MG)

Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger 4068, Norway.
Faculty of Health Sciences, University of Stavanger, Stavanger 4036, Norway.
Semillero de Neurociencias y Envejecimiento, Ageing Institute, Medical School, Pontificia Universidad Javeriana, Bogota 111611, Colombia.

Nadine Parker (N)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.

Vera Fominykh (V)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
ORCID: 0000-0001-5490-2390

Rikka Kjelkenes (R)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Department of Psychology, University of Oslo, Oslo 0373, Norway.
ORCID: 0000-0003-4793-4428

Jennifer Linge (J)

AMRA Medical AB, Linköping 58222, Sweden.
Department of Health, Medicine and Caring Sciences, Linköping University, Linköping 58183, Sweden.
ORCID: 0000-0001-7399-8375

Dennis van der Meer (D)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht 6200MD, The Netherlands.
ORCID: 0000-0002-0466-386X

Ida E Sønderby (IE)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Department of Medical Genetics, Oslo University Hospital, Oslo 0424, Norway.
ORCID: 0000-0001-7297-7855

Gustavo Duque (G)

Dr. Joseph Kaufmann Chair in Geriatric Medicine, Department of Medicine and Research Institute of the McGill University Health Centre, McGill University, Montreal, QC H4A 3J1, Canada.
ORCID: 0000-0001-8126-0637

Lars T Westlye (LT)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
Department of Psychology, University of Oslo, Oslo 0373, Norway.
ORCID: 0000-0001-8644-956X

Dag Aarsland (D)

Centre for Age-Related Medicine (SESAM), Stavanger University Hospital, Stavanger 4068, Norway.
Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London WC2R 2LS, UK.

Ole A Andreassen (OA)

Norwegian Centre for Mental Disorders Research (NORMENT), Division of Mental Health and Addiction, Oslo University Hospital and University of Oslo, Oslo 0424, Norway.
ORCID: 0000-0002-4461-3568

Classifications MeSH