Loss of Cardiac Splicing Regulator

We showed an association between atrial fibrillation and rare loss-of-function (LOF) variants in the cardiac splicing regulator RBM20 in 2 independent cohorts. In a rat model with loss of

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This work was supported by the Novo Nordisk Foundation, John and Birthe Meyer Foundation, Research Foundation of the Heart Centre Rigshospitalet, Villadsen Family Foundation, Arvid Nilsson Foundation, Danish Council for Independent Research, Research Foundation at Rigshospitalet, Skibsreder Per Henriksens R., og hustrus fond, and Department of Clinical Medicine (University of Copenhagen). Dr Ahlberg has received a grant from the Novo Nordisk Foundation, BRIDGE–Translational Excellence Programme. Dr Gotthardt was supported by the Deutsche Forschungsgemeinschaft and the Leducq Foundation. Dr Svendsen has received a fee for participating in the Advisory Board (Medtronic); and speaker fees from Medtronic not related to this work. Dr Gotthardt has a consultancy agreement with River BioMedics; and has received speaker honoraria from Bayer not related to this work. Dr Olesen has received speaker fees from Biosense Webster not related to this work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.