Comparison Between Moxifloxacin and Chloramphenicol for the Treatment of Bacterial Eye Infections.
Antibacterial activity
Antibiofilm
Cytotoxicity
Prophylaxis
Journal
Current therapeutic research, clinical and experimental
ISSN: 0011-393X
Titre abrégé: Curr Ther Res Clin Exp
Pays: United States
ID NLM: 0372621
Informations de publication
Date de publication:
2024
2024
Historique:
received:
11
09
2023
accepted:
21
02
2024
medline:
21
3
2024
pubmed:
21
3
2024
entrez:
21
3
2024
Statut:
epublish
Résumé
Moxifloxacin is a bactericidal methoxyquinolone used for the treatment of conjunctivitis and prophylactic therapy in cataract and refractive surgeries. Chloramphenicol is a bacteriostatic organochlorine introduced into clinical practice in 1948 and used mainly in topical preparations because of its known toxicity. The study aimed to evaluate the in vitro antibacterial effect and the ocular cytotoxicity of these broad-spectrum antibiotics. Antimicrobic activity was tested on 4 bacteria strains ( Cytotoxicity of antibiotics was evaluated on human epithelial corneal cells after 4 hours treatment by viability assay. Results showed that corneal cell viability was significantly higher after moxifloxacin treatment compared with chloramphenicol ( The lower corneal cell toxicity and the broader spectrum of antibacterial activity observed with moxifloxacin suggests its use in ophthalmic solution for the treatment of bacterial eye infections.
Sections du résumé
Background
UNASSIGNED
Moxifloxacin is a bactericidal methoxyquinolone used for the treatment of conjunctivitis and prophylactic therapy in cataract and refractive surgeries. Chloramphenicol is a bacteriostatic organochlorine introduced into clinical practice in 1948 and used mainly in topical preparations because of its known toxicity.
Objectives
UNASSIGNED
The study aimed to evaluate the in vitro antibacterial effect and the ocular cytotoxicity of these broad-spectrum antibiotics.
Methods
UNASSIGNED
Antimicrobic activity was tested on 4 bacteria strains (
Results
UNASSIGNED
Cytotoxicity of antibiotics was evaluated on human epithelial corneal cells after 4 hours treatment by viability assay. Results showed that corneal cell viability was significantly higher after moxifloxacin treatment compared with chloramphenicol (
Conclusions
UNASSIGNED
The lower corneal cell toxicity and the broader spectrum of antibacterial activity observed with moxifloxacin suggests its use in ophthalmic solution for the treatment of bacterial eye infections.
Identifiants
pubmed: 38511104
doi: 10.1016/j.curtheres.2024.100740
pii: S0011-393X(24)00010-9
pmc: PMC10950741
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100740Informations de copyright
© 2024 The Author(s).
Déclaration de conflit d'intérêts
The authors have indicated that they have no conflicts of interest regarding the content of this article.